دورية أكاديمية
Ancient chicken remains reveal the origins of virulence in Marek's disease virus.
| العنوان: | Ancient chicken remains reveal the origins of virulence in Marek's disease virus. |
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| المؤلفون: | Fiddaman SR; Department of Biology, University of Oxford, Oxford, UK., Dimopoulos EA; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Lebrasseur O; Centre d'Anthropobiologie et de Génomique de Toulouse, CNRS/Université Toulouse III Paul Sabatier, Toulouse, France.; Instituto Nacional de Antropología y Pensamiento Latinoamericano, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina., du Plessis L; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Vrancken B; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.; Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium., Charlton S; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK.; BioArCh, Department of Archaeology, University of York, York, UK., Haruda AF; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK., Tabbada K; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK., Flammer PG; Department of Biology, University of Oxford, Oxford, UK., Dascalu S; Department of Biology, University of Oxford, Oxford, UK., Marković N; Institute of Archaeology, Belgrade, Serbia., Li H; Institute of Immunity and Transplantation, University College London, London, UK., Franklin G; Silkie Club of Great Britain, Charing, UK., Symmons R; Fishbourne Roman Palace, Fishbourne, UK., Baron H; Leibniz-Zentrum für Archäologie, Mainz, Germany., Daróczi-Szabó L; Medieval Department, Budapest History Museum, Budapest, Hungary., Shaymuratova DN; Laboratory of Biomonitoring, The Institute of Problems in Ecology and Mineral Wealth, Tatarstan Academy of Sciences, Kazan, Russia., Askeyev IV; Laboratory of Biomonitoring, The Institute of Problems in Ecology and Mineral Wealth, Tatarstan Academy of Sciences, Kazan, Russia., Putelat O; Archéologie Alsace-PAIR, Sélestat, Bas-Rhin, France., Sana M; Departament de Prehistòria, Universitat Autònoma de Barcelona, Barcelona, Spain., Davoudi H; Bioarchaeology Laboratory, Central Laboratory, University of Tehran, Tehran, Iran., Fathi H; Bioarchaeology Laboratory, Central Laboratory, University of Tehran, Tehran, Iran., Mucheshi AS; Department of Art and Architecture, Payame Noor University (PNU), Tehran, Iran., Vahdati AA; Iranian Ministry of Cultural Heritage, Tourism, and Handicrafts, North Khorasan Office, Iran., Zhang L; Department of Archaeology, School of History, Nanjing University, China., Foster A; Headland Archaeology, Edinburgh, UK., Sykes N; Department of Archaeology, University of Exeter, Exeter, UK., Baumberg GC; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK., Bulatović J; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Askeyev AO; Laboratory of Biomonitoring, The Institute of Problems in Ecology and Mineral Wealth, Tatarstan Academy of Sciences, Kazan, Russia., Askeyev OV; Laboratory of Biomonitoring, The Institute of Problems in Ecology and Mineral Wealth, Tatarstan Academy of Sciences, Kazan, Russia., Mashkour M; Bioarchaeology Laboratory, Central Laboratory, University of Tehran, Tehran, Iran.; CNRS, National Museum Natural History Paris, Paris, France., Pybus OG; Department of Biology, University of Oxford, Oxford, UK.; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK., Nair V; Department of Biology, University of Oxford, Oxford, UK.; Viral Oncogenesis Group, Pirbright Institute, Woking, UK., Larson G; The Palaeogenomics and Bio-Archaeology Research Network, Research Laboratory for Archaeology and History of Art, University of Oxford, Oxford, UK., Smith AL; Department of Biology, University of Oxford, Oxford, UK., Frantz LAF; Palaeogenomics Group, Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, Ludwig-Maximilians-Universitat, Munich, Germany.; School of Biological and Chemical Sciences, Queen Mary University of London, London, UK. |
| المصدر: | Science (New York, N.Y.) [Science] 2023 Dec 15; Vol. 382 (6676), pp. 1276-1281. Date of Electronic Publication: 2023 Dec 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Chickens*/virology , Herpesvirus 2, Gallid*/classification , Herpesvirus 2, Gallid*/genetics , Herpesvirus 2, Gallid*/pathogenicity , Marek Disease*/history , Marek Disease*/virology, Animals ; Lymphoma/virology ; Virulence/genetics ; Phylogeny |
| مستخلص: | The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens. |
| معلومات مُعتمدة: | ERC-2019-STG-853272-PALAEOFARM International ERC_ European Research Council; 210119/Z/18/Z United Kingdom WT_ Wellcome Trust |
| تواريخ الأحداث: | Date Created: 20231214 Date Completed: 20231221 Latest Revision: 20231229 |
| رمز التحديث: | 20231229 |
| DOI: | 10.1126/science.adg2238 |
| PMID: | 38096384 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.adg2238 |