دورية أكاديمية
A new tidal breathing measurement device detects bronchial obstruction during methacholine challenge test.
| العنوان: | A new tidal breathing measurement device detects bronchial obstruction during methacholine challenge test. |
|---|---|
| المؤلفون: | Zachariades A; Nicosia Lung Center, Nicosia, Cyprus., Bachar N; NanoVation-GS LTD., Haifa, Israel. Electronic address: nadavb@nanovation-gs.com., Danino N; NanoVation-GS LTD., Haifa, Israel., Shafran I; NanoVation-GS LTD., Haifa, Israel., Shtrichman R; NanoVation-GS LTD., Haifa, Israel., Shuster G; NanoVation-GS LTD., Haifa, Israel., Voigt W; NanoVation-GS LTD., Haifa, Israel; Medical Innovation and Management, Steinbeis University Berlin, Berlin, Germany. |
| المصدر: | Advances in medical sciences [Adv Med Sci] 2024 Mar; Vol. 69 (1), pp. 1-7. Date of Electronic Publication: 2023 Dec 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101276222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1898-4002 (Electronic) Linking ISSN: 18961126 NLM ISO Abbreviation: Adv Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: March, 2014- : Amsterdam : Elsevier Original Publication: Białystok, Poland : Medical University of Białystok, [2006]- |
| مواضيع طبية MeSH: | Methacholine Chloride* , Bronchial Provocation Tests*/methods , Bronchial Provocation Tests*/instrumentation, Humans ; Male ; Female ; Adult ; Prospective Studies ; Spirometry/instrumentation ; Spirometry/methods ; Middle Aged ; Asthma/diagnosis ; Asthma/physiopathology ; Tidal Volume ; Young Adult ; Bronchial Hyperreactivity/diagnosis ; Bronchial Hyperreactivity/physiopathology |
| مستخلص: | Purpose: Bronchial hyperresponsiveness (BHR), a hallmark of bronchial asthma, is typically diagnosed through a methacholine inhalation test followed by spirometry, known as the methacholine challenge test (MCT). While spirometry relies on proper patients' cooperation and precise execution of forced breathing maneuvers, we conducted a comparative analysis with the portable nanomaterial-based sensing device, SenseGuard™, to non-intrusively assess tidal breathing parameters. Materials and Methods: In this prospective study, 37 adult participants with suspected asthma underwent sequential spirometry and SenseGuard™ measurements after inhaling increasing methacholine doses. Results: Among the 37 participants, 18 were MCT responders, 17 were non-responders and 2 were excluded due to uninterpretable data. The MCT responders exhibited a significant lung function difference when comparing the change from baseline to maximum response. This was evident through a notable decrease in forced expiratory volume in 1 s (FEV Conclusions: This study demonstrates that tidal breathing assessment using SenseGuard™ device reliably detects clinically relevant changes of respiratory parameter during the MCT. It effectively distinguishes between responders and non-responders, with strong agreement to conventional spirometry-measured FEV Competing Interests: Declaration of competing interest The authors declare no conflict of interests. (Copyright © 2023 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Asthma; Methacholine challenge test; Respiratory parameters; Tidal breathing; Wearable sensor |
| المشرفين على المادة: | 0W5ETF9M2K (Methacholine Chloride) |
| تواريخ الأحداث: | Date Created: 20231214 Date Completed: 20240502 Latest Revision: 20240502 |
| رمز التحديث: | 20240503 |
| DOI: | 10.1016/j.advms.2023.11.001 |
| PMID: | 38096771 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1898-4002 |
|---|---|
| DOI: | 10.1016/j.advms.2023.11.001 |