دورية أكاديمية
Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population.
| العنوان: | Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population. |
|---|---|
| المؤلفون: | Deva R; Pharmacology, JIPMER, Puducherry, India., Rajendran P; Pharmacology, JIPMER, Puducherry, India., Ramasamy S; Pharmacology, JIPMER, Puducherry, India., Selvan S; Pharmacology, JIPMER, Puducherry, India., Ramasamy K; Pharmacology, JIPMER, Puducherry, India. |
| المصدر: | Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2023 Dec 15; Vol. 39 (1), pp. 21-26. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: De Gruyter Country of Publication: Germany NLM ID: 101653409 Publication Model: eCollection Cited Medium: Internet ISSN: 2363-8915 (Electronic) Linking ISSN: 23638915 NLM ISO Abbreviation: Drug Metab Pers Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : De Gruyter, [2015]- |
| مواضيع طبية MeSH: | Azathioprine*/adverse effects , Drug-Related Side Effects and Adverse Reactions*, Humans ; Cross-Sectional Studies ; Genotype ; Immunosuppressive Agents/adverse effects ; Inosine Triphosphatase ; Polymorphism, Single Nucleotide/genetics |
| مستخلص: | Objectives: Azathioprine (AZA) is an effective immunosuppressant commonly used for malignancy and immune-mediated disorders. The association between genetic polymorphisms and AZA-induced adverse effects has not been elucidated. Hence this study aimed to evaluate the relationship between single nucleotide polymorphisms of ITPA (C94A) with azathioprine-induced adverse effects. Methods: A cross-sectional study was performed on 120 patients who were on AZA therapy for immunobullous disorders and inflammatory bowel disease (IBD). Eligible patients were enrolled from outpatient Departments of dermatology and medical gastroenterology and five mL of blood was collected after obtaining written informed consent. DNA extraction and genotyping were done by phenol-chloroform method and real-time polymerase chain reaction (RT-PCR), respectively. Results: The minor allele frequency of ITPA (A allele) was 30.8 %. The mutant genotypes of ITPA (C94A) were found to have no significant association with overall adverse effects in the South Indian patients on AZA therapy. Conclusions: We report no significant association between ITPA rs1127354 genetic polymorphism and adverse effects in the South Indian patients on AZA therapy. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
| References: | Cattaneo, D, Perico, N, Remuzzi, G. From pharmacokinetics to pharmacogenomics: a new approach to tailor immunosuppressive therapy: from pharmacokinetics to pharmacogenomics. Am J Transplant 2004;4:299–310, https://doi.org/10.1111/j.1600-6143.2004.00312.x . (PMID: 10.1111/j.1600-6143.2004.00312.x) Sahasranaman, S, Howard, D, Roy, S. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol 2008;64:753–67, https://doi.org/10.1007/s00228-008-0478-6 . (PMID: 10.1007/s00228-008-0478-6) Walker, GJ, Harrison, JW, Heap, GA, Voskuil, MD, Andersen, V, Anderson, CA, et al.. Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease. JAMA 2019;321:773–85, https://doi.org/10.1001/jama.2019.0709 . (PMID: 10.1001/jama.2019.0709) Jung, YS, Cheon, JH, Hong, SP, Kim, TI, Kim, WH. Clinical outcomes and prognostic factors for thiopurine maintenance therapy in patients with intestinal Behcetʼs disease. Inflamm Bowel Dis 2012;18:750–7, https://doi.org/10.1002/ibd.21757 . (PMID: 10.1002/ibd.21757) Khera, S, Trehan, A, Bhatia, P, Singh, M, Bansal, D, Varma, N. Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol 2019;83:341–8, https://doi.org/10.1007/s00280-018-3732-3 . (PMID: 10.1007/s00280-018-3732-3) Gisbert, JP, Gomolln, F. Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. Am J Gastroenterol 2008;103:1783–800, https://doi.org/10.1111/j.1572-0241.2008.01848.x . (PMID: 10.1111/j.1572-0241.2008.01848.x) Relling, MV, Hancock, ML, Rivera, GK, Sandlund, JT, Ribeiro, RC, Krynetski, EY, et al.. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst 1999;91:2001–8, https://doi.org/10.1093/jnci/91.23.2001 . (PMID: 10.1093/jnci/91.23.2001) Relling, MV, Gardner, EE, Sandborn, WJ, Schmiegelow, K, Pui, C-H, Yee, SW, et al.. Clinical pharmacogenetics implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update. Clin Pharmacol Ther 2013;93:324–5, https://doi.org/10.1038/clpt.2013.4 . (PMID: 10.1038/clpt.2013.4) Srimartpirom, S, Tassaneeyakul, W, Kukongviriyapan, V, Tassaneeyakul, W. Thiopurine S-methyltransferase genetic polymorphism in the Thai population. Br J Clin Pharmacol 2004;58:66–70, https://doi.org/10.1111/j.1365-2125.2004.02112.x . (PMID: 10.1111/j.1365-2125.2004.02112.x) Tanaka, Y, Manabe, A, Nakadate, H, Kondoh, K, Nakamura, K, Koh, K, et al.. The activity of the inosine triphosphate pyrophosphatase affects the toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children. Leuk Res 2012;36:560–4, https://doi.org/10.1016/j.leukres.2011.11.015 . (PMID: 10.1016/j.leukres.2011.11.015) Gopisankar, MG. Quality, quantity and recovery of DNA content from routine blood samples and genotyping success rate: comparison between phenol chloroform method (PCM) with a new kit-based DNA extraction method (KBM). Int J Basic Clin Pharmacol 2018;10:1863–8. Hardy-Weinberg Principle – an overview | ScienceDirect Topics [Internet] . Available from: https://www.sciencedirect.com/topics/neuroscience/hardy-weinberg-principle [accessed 6 Sep 2021]. Chen, Z-Y, Zhu, Y-H, Zhou, L-Y, Shi, W-Q, Qin, Z, Wu, B, et al.. Association between genetic polymorphisms of metabolic enzymes and azathioprine-induced myelosuppression in 1,419 Chinese patients: a retrospective study. Front Pharmacol 2021;12:672–9, https://doi.org/10.3389/fphar.2021.672769 . (PMID: 10.3389/fphar.2021.672769) Marinaki, AM, Duley, JA, Arenas, M, Ansari, A, Sumi, S, Lewis, CM, et al.. Mutation in the ITPA gene predicts intolerance to azathioprine. Nucleosides Nucleotides Nucleic Acids . 2004;23:1393–7, https://doi.org/10.1081/ncn-200027639 . (PMID: 10.1081/ncn-200027639) Citterio-Quentin, A, Moulsma, M, Gustin, M-P, Lachaux, A, Boulieu, R. ITPA activity in children treated by azathioprine: relationship to the occurrence of adverse drug reactions and inflammatory response. Basic Clin Pharmacol Toxicol 2018;122:588–95. Dorababu, P, Nagesh, N, Linga, VG, Gundeti, S, Kutala, VK, Reddanna, P, et al.. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. Eur J Clin Pharmacol 2012;68:379–87, https://doi.org/10.1007/s00228-011-1133-1 . (PMID: 10.1007/s00228-011-1133-1) Marinaki, AM, Ansari, A, Duley, JA, Arenas, M, Sumi, S, Lewis, CM, et al.. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004;14:181–7, https://doi.org/10.1097/00008571-200403000-00006 . (PMID: 10.1097/00008571-200403000-00006) Choi, R, Lee, M, Kim, K, Baek, S, Kim, TJ, Hong, SN, et al.. Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn’s disease. Br J Clin Pharmacol 2020;86:2302–13, https://doi.org/10.1111/bcp.14339 . (PMID: 10.1111/bcp.14339) |
| فهرسة مساهمة: | Keywords: azathioprine therapy; pharmacogenetics; pre-emptive testing |
| المشرفين على المادة: | MRK240IY2L (Azathioprine) 0 (Immunosuppressive Agents) EC 3.6.1.- (Inosine Triphosphatase) EC 3.6.1.9 (ITPA protein, human) |
| تواريخ الأحداث: | Date Created: 20231214 Date Completed: 20240411 Latest Revision: 20240418 |
| رمز التحديث: | 20240418 |
| DOI: | 10.1515/dmpt-2023-0061 |
| PMID: | 38097396 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!