دورية أكاديمية
Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population.
العنوان: | Association of ITPA 94C>A genetic polymorphisms with azathioprine induced adverse effects in the South Indian population. |
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المؤلفون: | Deva R; Pharmacology, JIPMER, Puducherry, India., Rajendran P; Pharmacology, JIPMER, Puducherry, India., Ramasamy S; Pharmacology, JIPMER, Puducherry, India., Selvan S; Pharmacology, JIPMER, Puducherry, India., Ramasamy K; Pharmacology, JIPMER, Puducherry, India. |
المصدر: | Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2023 Dec 15; Vol. 39 (1), pp. 21-26. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: De Gruyter Country of Publication: Germany NLM ID: 101653409 Publication Model: eCollection Cited Medium: Internet ISSN: 2363-8915 (Electronic) Linking ISSN: 23638915 NLM ISO Abbreviation: Drug Metab Pers Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : De Gruyter, [2015]- |
مواضيع طبية MeSH: | Azathioprine*/adverse effects , Drug-Related Side Effects and Adverse Reactions*, Humans ; Cross-Sectional Studies ; Genotype ; Immunosuppressive Agents/adverse effects ; Inosine Triphosphatase ; Polymorphism, Single Nucleotide/genetics |
مستخلص: | Objectives: Azathioprine (AZA) is an effective immunosuppressant commonly used for malignancy and immune-mediated disorders. The association between genetic polymorphisms and AZA-induced adverse effects has not been elucidated. Hence this study aimed to evaluate the relationship between single nucleotide polymorphisms of ITPA (C94A) with azathioprine-induced adverse effects. Methods: A cross-sectional study was performed on 120 patients who were on AZA therapy for immunobullous disorders and inflammatory bowel disease (IBD). Eligible patients were enrolled from outpatient Departments of dermatology and medical gastroenterology and five mL of blood was collected after obtaining written informed consent. DNA extraction and genotyping were done by phenol-chloroform method and real-time polymerase chain reaction (RT-PCR), respectively. Results: The minor allele frequency of ITPA (A allele) was 30.8 %. The mutant genotypes of ITPA (C94A) were found to have no significant association with overall adverse effects in the South Indian patients on AZA therapy. Conclusions: We report no significant association between ITPA rs1127354 genetic polymorphism and adverse effects in the South Indian patients on AZA therapy. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
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فهرسة مساهمة: | Keywords: azathioprine therapy; pharmacogenetics; pre-emptive testing |
المشرفين على المادة: | MRK240IY2L (Azathioprine) 0 (Immunosuppressive Agents) EC 3.6.1.- (Inosine Triphosphatase) EC 3.6.1.9 (ITPA protein, human) |
تواريخ الأحداث: | Date Created: 20231214 Date Completed: 20240411 Latest Revision: 20240418 |
رمز التحديث: | 20240418 |
DOI: | 10.1515/dmpt-2023-0061 |
PMID: | 38097396 |
قاعدة البيانات: | MEDLINE |
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