دورية أكاديمية
Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides.
| العنوان: | Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides. |
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| المؤلفون: | Saito Y; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; The Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan. Electronic address: yoshiro.saito.a8@tohoku.ac.jp., Noguchi N; The Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan., Niki E; Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Tokyo, Japan. Electronic address: etsuo-niki@emer.rcast.u-tokyo.ac.jp. |
| المصدر: | Free radical biology & medicine [Free Radic Biol Med] 2024 Feb 01; Vol. 211, pp. 89-95. Date of Electronic Publication: 2023 Dec 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| مواضيع طبية MeSH: | Phospholipids*/metabolism , Linoleic Acid*/metabolism, Humans ; Lipid Peroxidation ; Antioxidants/metabolism ; Cholesterol/metabolism ; Cell Membrane/metabolism ; Fatty Acids, Unsaturated/metabolism ; Linoleic Acids/metabolism |
| مستخلص: | Cholesterol is an essential component of cell membranes and serves as an important precursor of steroidal hormones and bile acids, but elevated levels of cholesterol and its oxidation products have been accepted as a risk factor for maintenance of health. The free and ester forms of cholesterol and fatty acids are the two major biological lipids. The aim of this hypothesis paper is to address the long-standing dogma that cholesterol is less susceptible to free radical peroxidation than polyunsaturated fatty acids (PUFAs). It has been observed that cholesterol is peroxidized much slower than PUFAs in plasma but that, contrary to expectations from chemical reactivity toward peroxyl radicals, cholesterol appears to be more readily autoxidized than linoleates in cell membranes. The levels of oxidation products of cholesterol and linoleates observed in humans support this notion. It is speculated that this discrepancy is ascribed to the fact that cholesterol and phospholipids bearing PUFAs are localized apart in raft and non-raft domains of cell membranes respectively and that the antioxidant vitamin E distributed predominantly in the non-raft domains cannot suppress the oxidation of cholesterol lying in raft domains which are relatively deficient in antioxidant. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cholesterol; Free radical peroxidation; Hydroperoxide; Lipid raft; Polyunsaturated fatty acids |
| المشرفين على المادة: | 7J48214Z9H (cholesterol hydroperoxide) 0 (Phospholipids) 9KJL21T0QJ (Linoleic Acid) 0 (Antioxidants) 97C5T2UQ7J (Cholesterol) 0 (Fatty Acids, Unsaturated) 0 (Linoleic Acids) |
| تواريخ الأحداث: | Date Created: 20231215 Date Completed: 20240108 Latest Revision: 20240217 |
| رمز التحديث: | 20240218 |
| DOI: | 10.1016/j.freeradbiomed.2023.12.011 |
| PMID: | 38101585 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4596 |
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| DOI: | 10.1016/j.freeradbiomed.2023.12.011 |