دورية أكاديمية
Nonhormonal Male Contraceptive Development-Strategies for Progress.
| العنوان: | Nonhormonal Male Contraceptive Development-Strategies for Progress. |
|---|---|
| المؤلفون: | Nickels L; Male Contraceptive Initiative, Durham, North Carolina (L.N.); The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California (W.Y.); and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (W.Y.) Logan@malecontraceptive.org wei.yan@lundquist.org., Yan W; Male Contraceptive Initiative, Durham, North Carolina (L.N.); The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California (W.Y.); and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (W.Y.) Logan@malecontraceptive.org wei.yan@lundquist.org. |
| المصدر: | Pharmacological reviews [Pharmacol Rev] 2023 Dec 15; Vol. 76 (1), pp. 37-48. Date of Electronic Publication: 2023 Dec 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0421737 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-0081 (Electronic) Linking ISSN: 00316997 NLM ISO Abbreviation: Pharmacol Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, Md : American Society for Pharmacology and Experimental Therapeutics Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Contraceptive Agents, Male*/pharmacology , Contraceptive Agents, Male*/therapeutic use, Male ; Humans ; Female ; Semen ; Contraception ; Contraceptive Agents ; Contraceptive Devices |
| مستخلص: | Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach. It further provides an overview of ongoing research and development on novel methods, with a goal to offer insights into the multifaceted aspects of nonhormonal male contraceptive development, addressing its implications for the health of men and women. SIGNIFICANCE STATEMENT: Despite well over half a century of effort in developing male contraceptives, there are no approved male contraceptive drugs on the market. This review aims to present strategies for progress in nonhormonal male contraception based on lessons learned from history, with the hope of expediting development and bringing a male contraceptive drug closer to reality. (Copyright © 2023 by The Author(s).) |
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| معلومات مُعتمدة: | R21 HD071736 United States HD NICHD NIH HHS; R01 HD085506 United States HD NICHD NIH HHS; R01 HD099924 United States HD NICHD NIH HHS; P30 GM110767 United States GM NIGMS NIH HHS; R61 HD114186 United States HD NICHD NIH HHS; P50 HD098593 United States HD NICHD NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS |
| المشرفين على المادة: | 0 (Contraceptive Agents, Male) 0 (Contraceptive Agents) |
| تواريخ الأحداث: | Date Created: 20231215 Date Completed: 20231218 Latest Revision: 20240205 |
| رمز التحديث: | 20240205 |
| مُعرف محوري في PubMed: | PMC10759220 |
| DOI: | 10.1124/pharmrev.122.000787 |
| PMID: | 38101934 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1521-0081 |
|---|---|
| DOI: | 10.1124/pharmrev.122.000787 |