دورية أكاديمية
أعرض في EDS

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.

التفاصيل البيبلوغرافية
العنوان: Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
المؤلفون: Navarro-Lobato I; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Masmudi-Martín M; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., López-Aranda MF; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., López-Téllez JF; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Delgado G; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Granados-Durán P; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Gaona-Romero C; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Carretero-Rey M; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Posadas S; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Quiros-Ortega ME; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain., Khan ZU; Laboratory of Neurobiology, Centro de Investigaciones Médico Sanitarias (CIMES), University of Malaga, Malaga, Spain.; Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Institute of Health Carlos III, Madrid, Spain.
المصدر: Neural regeneration research [Neural Regen Res] 2024 Aug 01; Vol. 19 (8), pp. 1835-1841. Date of Electronic Publication: 2023 Nov 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1673-5374 (Print) Linking ISSN: 16735374 NLM ISO Abbreviation: Neural Regen Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2013 - : Mumbai : Wolters Kluwer Health, Medknow
Original Publication: Shenyang : Editorial Board of Neural Regeneration Research
مستخلص: JOURNAL/nrgr/04.03/01300535-202408000-00038/figure1/v/2023-12-16T180322Z/r/image-tiff Memory deficit, which is often associated with aging and many psychiatric, neurological, and neurodegenerative diseases, has been a challenging issue for treatment. Up till now, all potential drug candidates have failed to produce satisfactory effects. Therefore, in the search for a solution, we found that a treatment with the gene corresponding to the RGS14414 protein in visual area V2, a brain area connected with brain circuits of the ventral stream and the medial temporal lobe, which is crucial for object recognition memory (ORM), can induce enhancement of ORM. In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative diseases such as Alzheimer's disease, produced long-lasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer's disease. Furthermore, we found that the prevention of memory deficits was mediated through the upregulation of neuronal arborization and spine density, as well as an increase in brain-derived neurotrophic factor (BDNF). A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer's disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits. These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer's disease. Therefore, our findings of RGS14414 gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.
(Copyright © 2024 Copyright: © 2024 Neural Regeneration Research.)
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تواريخ الأحداث: Date Created: 20231216 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC10960297
DOI: 10.4103/1673-5374.389301
PMID: 38103251
قاعدة البيانات: MEDLINE
الوصف
تدمد:1673-5374
DOI:10.4103/1673-5374.389301