دورية أكاديمية
Maternal risk factors for fetal alcohol spectrum disorders: Distal variables.
| العنوان: | Maternal risk factors for fetal alcohol spectrum disorders: Distal variables. |
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| المؤلفون: | May PA; Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa.; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA., Hasken JM; Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA., de Vries MM; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa., Marais AS; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa., Abdul-Rahman O; Department of Pediatrics, New York- Presbyterian Weill Cornell Medicine, Columbia University, New York, New York, USA., Robinson LK; Department of Pediatrics, State University of New York, Buffalo, New York, USA., Adam MP; Department of Pediatrics, University of Washington, Seattle, Washington, USA., Manning MA; Department of Pathology and Pediatrics, Stanford University School of Medicine, Stanford, California, USA., Kalberg WO; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA., Buckley D; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA., Snell CL; School of Social Work, Howard University, Washington, District of Columbia, USA., Seedat S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa., Parry CDH; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa.; Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Francie van Zijl Drive, Cape Town, South Africa., Hoyme HE; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch Universitye, Cape Town, South Africa.; Sanford Children's Genomic Medicine Consortium, Sanford Health, Sioux Falls, South Dakota, USA. |
| المصدر: | Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2024 Feb; Vol. 48 (2), pp. 319-344. Date of Electronic Publication: 2024 Jan 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 9918609780906676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2993-7175 (Electronic) Linking ISSN: 29937175 NLM ISO Abbreviation: Alcohol Clin Exp Res (Hoboken) Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : Wiley Periodicals, [2023]- |
| مستخلص: | Background: A variety of maternal risk factors for fetal alcohol spectrum disorders (FASD) have been described in the literature. Here, we conducted a multivariate analysis of a large array of potential distal influences on FASD risk. Methods: Interviews were conducted with 2515 mothers of first-grade students whose children were evaluated to assess risk for FASD. Topics included: physical/medical status, childbearing history, demographics, mental health, domestic violence, and trauma. Regression modeling utilized usual level of alcohol consumption by trimester and six selected distal variables (maternal head circumference, body mass index, age at pregnancy, gravidity, marital status, and formal years of education) to differentiate children with FASD from control children. Results: Despite individual variation in distal maternal risk factors among and within the mothers of children with each of the common diagnoses of FASD, patterns emerged that differentiated risk among mothers of children with FASD from mothers whose children were developing typically. Case-control comparisons indicate that mothers of children with FASD were significantly smaller physically, had higher gravidity and parity, and experienced more miscarriages and stillbirths, were less likely to be married, reported later pregnancy recognition, more depression, and lower formal educational achievement. They were also less engaged with a formal religion, were less happy, suffered more childhood trauma and interpersonal violence, were more likely to drink alone or with her partner, and drank to deal with anxiety, tension, and to be part of a group. Regression analysis showed that the predictor variables explain 57.5% of the variance in fetal alcohol syndrome (FAS) diagnoses, 30.1% of partial FAS (PFAS) diagnoses, and 46.4% of alcohol-related neurodevelopmental disorder (ARND) diagnoses in children with FASD compared to controls. While the proximal variables explained most of the diagnostic variance, six distal variables explained 16.7% ( 1 / Conclusions: Differences in distal FASD risks were identified. Complex models to quantify risk for FASD hold promise for guiding prevention/intervention. (© 2023 Research Society on Alcohol.) |
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| معلومات مُعتمدة: | R01 AA015134 United States AA NIAAA NIH HHS; R61 AA030066 United States AA NIAAA NIH HHS; AA015134 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: South Africa; fetal alcohol spectrum disorders; maternal risk for FASD; prenatal alcohol use |
| تواريخ الأحداث: | Date Created: 20231217 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| مُعرف محوري في PubMed: | PMC10922553 |
| DOI: | 10.1111/acer.15246 |
| PMID: | 38105110 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2993-7175 |
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| DOI: | 10.1111/acer.15246 |