دورية أكاديمية

A Retrospective Comparison of Electrocardiographic Parameters in Ketamine and Tiletamine-Zolazepam Anesthetized Indian Rhesus Monkeys ( Macaca mulatta ).

التفاصيل البيبلوغرافية
العنوان: A Retrospective Comparison of Electrocardiographic Parameters in Ketamine and Tiletamine-Zolazepam Anesthetized Indian Rhesus Monkeys ( Macaca mulatta ).
المؤلفون: Bhatt LK; Zydus Lifesciences Limited, Ahmedabad, India., Shah CR; Zydus Lifesciences Limited, Ahmedabad, India., Patel SD; Zydus Lifesciences Limited, Ahmedabad, India., Patel SR; Zydus Lifesciences Limited, Ahmedabad, India., Patel VA; Zydus Lifesciences Limited, Ahmedabad, India., Patel RJ; Zydus Lifesciences Limited, Ahmedabad, India., Joshi NM; Zydus Lifesciences Limited, Ahmedabad, India., Shah NA; Zydus Lifesciences Limited, Ahmedabad, India., Patel JH; Zydus Lifesciences Limited, Ahmedabad, India., Dwivedi P; Zydus Lifesciences Limited, Ahmedabad, India., Sundar R; Zydus Lifesciences Limited, Ahmedabad, India., Jain MR; Zydus Lifesciences Limited, Ahmedabad, India.
المصدر: International journal of toxicology [Int J Toxicol] 2024 Mar-Apr; Vol. 43 (2), pp. 184-195. Date of Electronic Publication: 2023 Dec 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2009- : Thousand Oaks, CA : Sage Publications
Original Publication: Washington, DC : Taylor & Francis, c1997-
مواضيع طبية MeSH: Ketamine*/toxicity , Anesthetics*/toxicity, Animals ; Humans ; Male ; Female ; Tiletamine/toxicity ; Macaca mulatta ; Zolazepam/toxicity ; Retrospective Studies ; Heart Rate
مستخلص: Electrocardiographic evaluation is performed in rhesus monkeys to establish the cardiovascular safety of candidate molecules before progressing to clinical trials. These animals are usually immobilized chemically by ketamine (KTM) and tiletamine-zolazepam (TZ) to obtain a steady-state heart rate and to ensure adequate human safety. The present study aimed to evaluate the effect of these anesthetic regimens on different electrocardiographic parameters. Statistically significant lower HR and higher P-wave duration, RR, QRS, and QT intervals were observed in the KTM-anesthetized group in comparison to TZ-anesthetized animals. No significant changes were noticed in the PR interval and p-wave amplitude. Sex-based significance amongst these parameters was observed in male and female animals of TZ- and KTM-anesthetized groups. Regression analysis of four QTc formulas in TZ-anesthetized rhesus monkeys revealed that QTcNAK (Nakayama) better corrected the QT interval than QTcHAS (Hassimoto), QTcBZT (Bazett), and QTcFRD (Fridericia) formulas. QTcNAK exhibited the least correlation with the RR interval (slope closest to zero and r = .01) and displayed no statistical significance between male and female animals. These data will prove useful in the selection of anesthetic regimens for chemical restraint of rhesus monkeys in nonclinical safety evaluation studies.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
فهرسة مساهمة: Keywords: QT prolongation; cardiovascular safety; electrocardiography; historical control data; nonhuman primates
المشرفين على المادة: 690G0D6V8H (Ketamine)
2YFC543249 (Tiletamine)
G1R474U58U (Zolazepam)
0 (Anesthetics)
تواريخ الأحداث: Date Created: 20231218 Date Completed: 20240306 Latest Revision: 20240306
رمز التحديث: 20240306
DOI: 10.1177/10915818231221276
PMID: 38108647
قاعدة البيانات: MEDLINE
الوصف
تدمد:1092-874X
DOI:10.1177/10915818231221276