دورية أكاديمية
A case of subarachnoid haemorrhage associated with MPO-ANCA-positive eosinophilic granulomatosis with polyangiitis, successfully treated with glucocorticoid, cyclophosphamide, and mepolizumab.
| العنوان: | A case of subarachnoid haemorrhage associated with MPO-ANCA-positive eosinophilic granulomatosis with polyangiitis, successfully treated with glucocorticoid, cyclophosphamide, and mepolizumab. |
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| المؤلفون: | Satake Y; Department of Internal Medicine, Nagaoka Red Cross Hospital, Niigata, Japan., Sakai S; Department of Internal Medicine, Nagaoka Red Cross Hospital, Niigata, Japan., Takao T; Department of Neurosurgery, Nagaoka Red Cross Hospital, Niigata, Japan., Saeki T; Department of Internal Medicine, Nagaoka Red Cross Hospital, Niigata, Japan. |
| المصدر: | Modern rheumatology case reports [Mod Rheumatol Case Rep] 2024 Jul 08; Vol. 8 (2), pp. 310-313. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101761026 Publication Model: Print Cited Medium: Internet ISSN: 2472-5625 (Electronic) Linking ISSN: 24725625 NLM ISO Abbreviation: Mod Rheumatol Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Oxford : Oxford University Press Original Publication: Abingdon, Oxfordshire : Taylor & Francis, [2017]- |
| مواضيع طبية MeSH: | Cyclophosphamide*/therapeutic use , Cyclophosphamide*/administration & dosage , Subarachnoid Hemorrhage*/etiology , Subarachnoid Hemorrhage*/diagnosis , Subarachnoid Hemorrhage*/complications , Subarachnoid Hemorrhage*/drug therapy , Glucocorticoids*/therapeutic use , Glucocorticoids*/administration & dosage , Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/administration & dosage , Antibodies, Antineutrophil Cytoplasmic*/immunology , Immunosuppressive Agents*/therapeutic use , Immunosuppressive Agents*/administration & dosage, Humans ; Treatment Outcome ; Churg-Strauss Syndrome/diagnosis ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/drug therapy ; Peroxidase/immunology ; Granulomatosis with Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/complications ; Male ; Drug Therapy, Combination ; Middle Aged ; Female |
| مستخلص: | Subarachnoid haemorrhage (SAH) is a quite rare but serious central nervous system complication of eosinophilic granulomatosis with polyangiitis (EGPA). We report a case of myeloperoxidase antineutrophil cytoplasmic antibody-positive EGPA in which SAH developed during glucocorticoid induction pulse therapy for skin purpura, peripheral neuropathy, and rapidly progressive glomerulonephritis. In addition to high-dose glucocorticoid and intravenous cyclophosphamide, we administered mepolizumab, a humanised anti-interleukin-5 monoclonal antibody, and this resulted in remission of the SAH. Although the pathogenesis of SAH in EGPA is not fully understood, both necrotising vasculitis and eosinophilic inflammation are thought to be involved. In addition to prompt intensive immunosuppressive therapy, mepolizumab should be considered for SAH associated with EGPA. (© Japan College of Rheumatology 2023. Published by Oxford University Press.) |
| فهرسة مساهمة: | Keywords: Eosinophilic granulomatosis with polyangiitis; MPO-ANCA; mepolizumab; subarachnoid haemorrhage |
| المشرفين على المادة: | 8N3DW7272P (Cyclophosphamide) 0 (Glucocorticoids) 90Z2UF0E52 (mepolizumab) 0 (Antibodies, Monoclonal, Humanized) 0 (Antibodies, Antineutrophil Cytoplasmic) 0 (Immunosuppressive Agents) EC 1.11.1.7 (Peroxidase) |
| تواريخ الأحداث: | Date Created: 20231218 Date Completed: 20240708 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1093/mrcr/rxad071 |
| PMID: | 38109745 |
| قاعدة البيانات: | MEDLINE |
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