دورية أكاديمية
أعرض في EDS

Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis.

التفاصيل البيبلوغرافية
العنوان: Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis.
المؤلفون: Iglesies-Grau J; Research Center and Centre ÉPIC, Montreal Heart Institute, Montréal, Canada.; Universitat de Girona, Girona, Spain., Garcia-Alvarez A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; Cardiology Departement, Institut Clinic Cardiovascular, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Oliva B; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain., Mendieta G; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; Cardiology Departement, Institut Clinic Cardiovascular, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., García-Lunar I; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Cardiology Department, University Hospital La Moraleja, Madrid, Spain., Fuster JJ; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Devesa A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA., Pérez-Herreras C; Medical Services, Banco Santander, Madrid, Spain., Fernández-Ortiz A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; Hospital Universitario Clínico San Carlos, Madrid, Spain., Brugada R; Universitat de Girona, Girona, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Department of Cardiology, Hospital Universitari Dr. Josep Trueta, Girona, Spain.; Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain., Ibanez B; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; IIS-Fundación Jiménez Díaz University Hospital, Madrid, Spain., Fernandez-Jimenez R; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain. rfernandez@cnic.es.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. rfernandez@cnic.es.; Hospital Universitario Clínico San Carlos, Madrid, Spain. rfernandez@cnic.es., Fuster V; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro, 3, Madrid, 28029, Spain. vfuster@cnic.es.; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA. vfuster@cnic.es.
المصدر: Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Dec 19; Vol. 22 (1), pp. 350. Date of Electronic Publication: 2023 Dec 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Insulin Resistance* , Atherosclerosis*/diagnostic imaging , Atherosclerosis*/epidemiology , Plaque, Atherosclerotic*, Middle Aged ; Humans ; Glycated Hemoglobin ; Risk Factors
مستخلص: Background: Elevated glycated hemoglobin (HbA1c) is associated with a higher burden of subclinical atherosclerosis (SA). However, the association with SA of earlier insulin resistance markers is poorly understood. The study assessed the association between the homeostatic model assessment of insulin resistance index (HOMA-IR) and SA in addition to the effect of cardiovascular risk factors (CVRFs) in individuals with normal HbA1c.
Methods: A cohort of 3,741 middle-aged individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study with basal HbA1c < 6.0% (< 42 mmol/mol) and no known CV disease underwent extensive imaging (multiterritorial vascular ultrasound and coronary artery calcium score, CACS) to assess the presence, burden, and extent of SA.
Results: Individuals with higher HOMA-IR values had higher rates of CVRFs. HOMA-IR showed a direct association with the multiterritorial extent of SA and CACS (p < 0.001) and with global plaque volume measured by 3-dimensional vascular ultrasound (p < 0.001). After adjusting for key CVRFs and HbA1c, HOMA-IR values ≥ 3 were associated with both the multiterritorial extent of SA (odds ratio 1.41; 95%CI: 1.01 to 1.95, p = 0.041) and CACS > 0 (odds ratio 1.74; 95%CI: 1.20 to 2.54, p = 0.004), as compared with the HOMA-IR < 2 (the reference HOMA-IR category). In a stratified analysis, this association remained significant in individuals with a low-to-moderate SCORE2 risk estimate (75.6% of the cohort) but not in high-risk individuals.
Conclusions: The use of HOMA-IR identified low-risk individuals with a higher burden of SA, after adjusting for the effects of key traditional CVRFs and HbA1c. HOMA-IR is a simple measure that could facilitate earlier implementation of primary CV prevention strategies in clinical practice.
(© 2023. The Author(s).)
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معلومات مُعتمدة: PI15/02019 Instituto de Salud Carlos III; PI15/02019 Instituto de Salud Carlos III; PI22/01560 Instituto de Salud Carlos III; PI15/02019 Instituto de Salud Carlos III; CEX2020-001041-S Ministerio de Ciencia e Innovación; CEX2020-001041-S Ministerio de Ciencia e Innovación
فهرسة مساهمة: Keywords: Atherosclerosis; Cardiovascular disease; Imaging; Insulin resistance; Primary disease prevention
المشرفين على المادة: 0 (Glycated Hemoglobin)
تواريخ الأحداث: Date Created: 20231220 Date Completed: 20231221 Latest Revision: 20240313
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10731750
DOI: 10.1186/s12933-023-02090-1
PMID: 38115031
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2840
DOI:10.1186/s12933-023-02090-1