دورية أكاديمية
أعرض في EDS

The Assessment of Radial Peripapillary Capillary Vessel Density in Adult Children of Patients With Primary Open Angle Glaucoma.

التفاصيل البيبلوغرافية
العنوان: The Assessment of Radial Peripapillary Capillary Vessel Density in Adult Children of Patients With Primary Open Angle Glaucoma.
المؤلفون: Bayraktar S; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Hondur G; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Şekeroğlu MA; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Altaş FB; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Yeşilyaprak N; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Çevik S; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Şen E; The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Elgin U; Dünyagöz Eye Hospital, Ankara, Turkey.
المصدر: Journal of glaucoma [J Glaucoma] 2024 Jul 01; Vol. 33 (7), pp. e43-e48. Date of Electronic Publication: 2023 Dec 21.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, N.Y. : Raven Press, c1992-
مواضيع طبية MeSH: Glaucoma, Open-Angle*/diagnosis , Glaucoma, Open-Angle*/physiopathology , Tomography, Optical Coherence*/methods , Nerve Fibers*/pathology , Retinal Vessels*/diagnostic imaging , Retinal Vessels*/pathology , Capillaries*/pathology , Capillaries*/diagnostic imaging , Optic Disk*/blood supply , Retinal Ganglion Cells*/pathology , Intraocular Pressure*/physiology , Visual Fields*/physiology, Humans ; Female ; Male ; Adult ; Microvascular Density ; Fluorescein Angiography/methods ; Middle Aged
مستخلص: Prcis: The observed decrease in radial peripapillary capillary vessel density among adult children of individuals with primary open angle glaucoma, in comparison to controls, suggests the possibility of early microvascular alterations in the eyes of these at-risk individuals.
Purpose: To compare the radial peripapillary capillary vessel density (RPCVD) and peripapillary retinal nerve fiber layer (RNFL) thickness values of eyes between healthy adults with a maternal or paternal history of primary open angle glaucoma (POAG) and age-matched healthy controls without a family history of POAG.
Materials and Methods: RPCVD values and RNFL thicknesses in the peripapillary region and 4 quadrants (superior, inferior, nasal, and temporal) were evaluated using optical coherence tomography angiography among 30 adult children of patients with POAG and 30 age-matched healthy controls without a family history of POAG.
Results: The mean whole image RPCVD (51.6±1.7% vs. 49.8±1.7%, P =0.0006) and average RPCVD (54.7±1.7% vs. 53.2±2.1%, P =0.006) values were significantly lower in the adult children of patients with POAG compared with age-matched healthy controls without a family history of POAG. There was no difference in terms of RNFL thickness values in any region.
Conclusion: Despite having similar RNFL thickness values to the control group, the observation of lower RPCVD in the eyes of adult children of POAG patients may indicate potential early vascular alterations. The result of the present study encourages further longitudinal studies to determine the potential importance of the underlying vascular alterations in these high-risk individuals.
Competing Interests: Disclosure: The authors declare no conflict of interest.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
References: Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: A review. JAMA. 2014;311:1901–1911.
Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262–267.
Vistamehr S, Shelsta HN, Palmisano PC, et al. Glaucoma screening in a high-risk population. J Glaucoma. 2006;15:534–540.
Bilgin S. The evaluation of retinal nerve fiber layer and ganglion cell complex thickness in adult offspring of primary open-angle glaucoma patients. J Glaucoma. 2020;29:819–822.
Nagar A, Myers S, Kozareva D, et al. Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London. Br J Ophthalmol. 2022;106:376–380.
Rajendrababu S, Gupta N, Vijayakumar B, et al. Screening first degree relatives of persons with primary open angle glaucoma in India. J Curr Glaucoma Pract. 2014;8:107–112.
Ogunleye O, Olawoye O, Sarimiye T, et al. The effect of direct health education on the uptake of screening by first degree relatives of glaucoma patients in Nigeria. J Glaucoma. 2021;30:395–401.
Wolfs RC, Klaver CC, Ramrattan RS, et al. Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol. 1998;116:1640–1645.
Tielsch JM, Katz J, Sommer A, et al. Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Arch Ophthalmol. 1994;112:69–73.
Rolle T, Dallorto L, Briamonte C, et al. Retinal nerve fibre layer and macular thickness analysis with Fourier domain optical coherence tomography in subjects with a positive family history for primary open angle glaucoma. Br J Ophthalmol. 2014;98:1240–1244.
Medeiros FA, Zangwill LM, Bowd C, et al. Evaluation of retinal nerve fiber layer, optic nerve head and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol. 2005;139:44–55.
Karti O, Yuksel B, Uzunel UD, et al. The assessment of optical coherence tomographic parameters in subjects with a positive family history of glaucoma. Clin Exp Optom. 2017;100:663–667.
Pekel G, Acer S, Yagci R, et al. Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of glaucoma patients. Kaohsiung J Med Sci. 2015;31:420–425.
Nakazawa T. Ocular blood flow and influencing factors for glaucoma. Asia Pac J Ophthalmol (Phila). 2016;5:38–44.
Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–393.
Tobe LA, Harris A, Hussain RM, et al. The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period. Br J Ophthalmol. 2015;99:609–612.
Wang X, Jiang C, Ko T, et al. Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol. 2015;253:1557–1564.
Yarmohammadi A, Zangwill LM, Diniz-Filho A, et al. Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. Invest Ophthalmol Vis Sci. 2016;57:OCT451–OCT459.
Lu P, Xiao H, Liang C, et al. Quantitative analysis of microvasculature in macular and peripapillary regions in early primary open-angle glaucoma. Curr Eye Res. 2020;45:629–635.
Mansoori T, Sivaswamy J, Gamalapati JS, et al. Radial peripapillary capillary density measurement using optical coherence tomography angiography in early glaucoma. J Glaucoma. 2017;26:438–443.
de Mul M, de Bont AA, Reus NJ, et al. Improving the quality of eye care with tele-ophthalmology: Shared-care glaucoma screening. J Telemed Telecare. 2004;10:331–336.
Bekkers A, Borren N, Ederveen V, et al. Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions. Acta Ophthalmol. 2020;98:537–558.
Kawasaki R, Wang JJ, Rochtchina E, et al. Retinal vessel caliber is associated with the 10-year incidence of glaucoma: The Blue Mountains Eye Study. Ophthalmology. 2013;120:84–90.
Bayraktar S, İpek A, Takmaz T, et al. Ocular blood flow and choroidal thickness in ocular hypertension. Int Ophthalmol. 2022;42:1357–1368.
Zeitz O, Galambos P, Wagenfeld L, et al. Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. Br J Ophthalmol. 2006;90:1245–1248.
Findl O, Rainer G, Dallinger S, et al. Assessment of optic disk blood flow in patients with open-angle glaucoma. Am J Ophthalmol. 2000;130:589–596.
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20240626 Latest Revision: 20240626
رمز التحديث: 20240626
DOI: 10.1097/IJG.0000000000002347
PMID: 38129936
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-481X
DOI:10.1097/IJG.0000000000002347