دورية أكاديمية
أعرض في EDS

Histopathology and electron microscopy evaluation of the sildenafil effect on diabetic rats' retinae.

التفاصيل البيبلوغرافية
العنوان: Histopathology and electron microscopy evaluation of the sildenafil effect on diabetic rats' retinae.
المؤلفون: Tadros D; Department of Ophthalmology, Faculty of Medicine, Tanta University, Egypt., Abdelhalim TI; Department of Ophthalmology, Faculty of Medicine, Tanta University, Egypt., Sarhan N; Department of Histology, Faculty of Medicine, Tanta University, Egypt., El-Anwar N; Department of Pathology, Faculty of Medicine, Tanta University, Egypt.; Department of Pathology, Armed Forces, College of Medicine, Egypt., Elkholy RA; Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt.; Department of Pharmacology, School of Medicine, Badr University In Cairo, Egypt., Tahoon D; Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt., Sorour OA; Department of Ophthalmology, Faculty of Medicine, Tanta University, Egypt.
المصدر: Indian journal of ophthalmology [Indian J Ophthalmol] 2024 Jan 01; Vol. 72 (Suppl 1), pp. S111-S118. Date of Electronic Publication: 2023 Dec 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Bombay : All-India Ophthalmological Society
مواضيع طبية MeSH: Diabetic Retinopathy*/diagnosis , Diabetic Retinopathy*/drug therapy , Diabetes Mellitus, Experimental*/complications, Rats ; Male ; Animals ; Sildenafil Citrate/pharmacology ; Rats, Sprague-Dawley ; Microscopy, Electron
مستخلص: Purpose: Although there is increasing evidence that phosphodiesterase-5 (PDE-5) inhibitors modify the effect of diabetes on different tissues, its effect on diabetic retinopathy is not well studied.
Methods: Forty male Sprague-Dawley (SD) rats were divided into four groups: group I = control group that received no treatment; group II (diabetic group), in which diabetes was induced by a single streptozotocin injection; group III (sildenafil small dose, SSD), in which diabetes was similarly introduced (however, rats received daily oral 1 mg/kg sildenafil citrate (SC) for 3 months); and group IV (sildenafil large dose, SLD), which was as in group 3, but SC was 2.5 mg/kg. After 3 months, globes were removed and retinae were dissected; one globe from each rat was examined by light microscopy (LM), and the other by electron microscopy (EM).
Results: In contrast to the control group, diabetic rats in group II demonstrated well-established diabetic changes in the form of capillary congestion, decreased cell population, hyaline changes of capillary walls, and degenerated nerve fiber layer by LM. Similarly, EM demonstrated photoreceptor degeneration, mitochondrial cristolysis, and vacuolated depleted cells among other features in group II. These diabetic features were less prominent in group III and nearly absent in group IV.
Conclusion: SC use in the early stages of DR may prevent/delay diabetic retinopathy development or progression in diabetic rat models, an effect that seems to be dose-related.
(Copyright © 2023 Copyright: © 2023 Indian Journal of Ophthalmology.)
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المشرفين على المادة: BW9B0ZE037 (Sildenafil Citrate)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20240203
رمز التحديث: 20240205
مُعرف محوري في PubMed: PMC10833156
DOI: 10.4103/IJO.IJO_976_23
PMID: 38131552
قاعدة البيانات: MEDLINE
الوصف
تدمد:1998-3689
DOI:10.4103/IJO.IJO_976_23