دورية أكاديمية
Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer.
| العنوان: | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer. |
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| المؤلفون: | Cilio S; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Tufano A; Department of Maternal-Infant and Urological Sciences, Policlinico Umberto I Hospital, 'Sapienza' Rome University, 00161 Rome, Italy., Pezone G; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Alvino P; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Spena G; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Pandolfo SD; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Del Prete P; Scientific Directorate, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131 Naples, Italy., Amato C; Dipartimento di Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy., Damiano R; Urology Unit, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Salonia A; Unit of Urology/Division of Experimental Oncology, URI, IRCCS Ospedale San Raffaele, 20141 Milan, Italy., Autorino R; Department of Urology, Rush University Medical Center, Chicago, IL 60637, USA., Izzo A; Uro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131 Naples, Italy., Passaro F; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', 80131 Naples, Italy., Perdonà S; Uro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131 Naples, Italy. |
| المصدر: | Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Dec 17; Vol. 30 (12), pp. 10501-10508. Date of Electronic Publication: 2023 Dec 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Toronto : Multimed, c1994- |
| مواضيع طبية MeSH: | Erectile Dysfunction*/psychology , Penile Neoplasms*/surgery, Male ; Humans ; Penile Erection ; Conservative Treatment ; Penis/surgery |
| مستخلص: | Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri's criteria. Results: Overall, 34 patients with PC confined to the glans (c ≤ T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF < 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: -2.41) and those that underwent glansectomy (Coeff: -7.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC ≤ T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively. |
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| فهرسة مساهمة: | Keywords: CSFQ; IIEF-5; erectile function; glansectomy; localized penile cancer; penile cancer; penile neoplasm; penile-sparing surgery; quality of life; sexual dysfunction; wide local resection |
| تواريخ الأحداث: | Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| مُعرف محوري في PubMed: | PMC10742874 |
| DOI: | 10.3390/curroncol30120765 |
| PMID: | 38132399 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1718-7729 |
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| DOI: | 10.3390/curroncol30120765 |