دورية أكاديمية
أعرض في EDS

Indocyanine green: A novel marker for assessment of graft quality during ex situ normothermic machine perfusion of human livers.

التفاصيل البيبلوغرافية
العنوان: Indocyanine green: A novel marker for assessment of graft quality during ex situ normothermic machine perfusion of human livers.
المؤلفون: Lau NS; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Ly M; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Ewenson K; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Toomath S; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Ly H; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Mestrovic N; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Liu K; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., McCaughan G; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Crawford M; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Pulitano C; Centre for Organ Assessment, Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
المصدر: Artificial organs [Artif Organs] 2024 May; Vol. 48 (5), pp. 472-483. Date of Electronic Publication: 2023 Dec 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7802778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1594 (Electronic) Linking ISSN: 0160564X NLM ISO Abbreviation: Artif Organs Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Wiley-Blackwell
Original Publication: Cleveland, International Society for Artificial Organs.
مواضيع طبية MeSH: Indocyanine Green* , Liver Transplantation*/adverse effects, Humans ; Liver/surgery ; Perfusion ; Organ Preservation
مستخلص: Background: Ex situ machine perfusion facilitates the assessment of livers prior to transplantation. However, currently available markers of liver function poorly predict long-term graft function. Indocyanine green (ICG) is a liver-specific dye which, although common in vivo, has never been comprehensively evaluated for the assessment of graft quality during ex situ machine perfusion. This study aimed to assess the utility of ICG in the ex situ setting.
Methods: Using a customized long-term perfusion system, human livers that were not suitable for transplantation were perfused using a red cell-based perfusate. ICG was delivered into the perfusate on days 0, 1, and 4 to assess ICG clearance (spectrophotometric absorbance at 805 nm) and ICG fluorescence (near-infrared camera).
Results: Sixteen partial livers were perfused for a median duration of 172 h (7.2 days). On day 0, the median ICG perfusate disappearance rate (PDR) was 7.5%/min and the median ICG retention at 15 min was 9.9%. Grafts that survived ≥7 days had a significantly higher median ICG PDR on day 0 (14.5%/min vs. 6.5%/min, p = 0.005) but not on days 1 or 4. ICG perfusion demonstrated that long-surviving grafts had a significantly lower median red-value (89.8 vs. 118.6, p = 0.011) and a significantly lower median blue-value (12.9 vs. 22.6, p = 0.045) than short-surviving grafts.
Conclusion: ICG is a novel marker for the assessment of liver function during ex situ normothermic machine perfusion. ICG PDR and quantitative ICG perfusion can distinguish between long- and short-surviving grafts and demonstrate the utility of ICG in the assessment of graft quality prior to transplant.
(© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: ex situ; indocyanine green; normothermic machine perfusion; viability assessment
المشرفين على المادة: IX6J1063HV (Indocyanine Green)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20240418 Latest Revision: 20240418
رمز التحديث: 20240418
DOI: 10.1111/aor.14696
PMID: 38132848
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-1594
DOI:10.1111/aor.14696