دورية أكاديمية
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Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus Phomopsis sp. QYM-13.

التفاصيل البيبلوغرافية
العنوان: Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus Phomopsis sp. QYM-13.
المؤلفون: Wang G; School of Pharmacy, Anhui Medical University, Hefei 230032, China.; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China., Yuan Y; National R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China., Li Z; School of Pharmacy, Anhui Medical University, Hefei 230032, China., Zhu J; School of Pharmacy, Anhui Medical University, Hefei 230032, China., She Z; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China., Chen Y; School of Pharmacy, Anhui Medical University, Hefei 230032, China.
المصدر: Marine drugs [Mar Drugs] 2023 Dec 07; Vol. 21 (12). Date of Electronic Publication: 2023 Dec 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Phomopsis* , Fungi*, Molecular Docking Simulation ; Anti-Inflammatory Agents/pharmacology ; Signal Transduction ; Molecular Structure
مستخلص: Six previously undescribed cytosporone derivatives (phomotones A-E ( 1 - 5 ) and phomotone F ( 13 )), two new spiro-alkanol phombistenes A-B ( 14 - 15 ), and seven known analogs ( 6 - 12 ) were isolated from the mangrove endophytic fungus Phomopsis sp. QYM-13. The structures of these compounds were elucidated using spectroscopic data analysis, electronic circular dichroism (ECD), and 13 C NMR calculations. Compound 14 features an unprecedented 1,6-dioxaspiro[4.5]decane ring system. All isolates were evaluated for their inhibitory effect on nitric oxide (NO) in LPS-induced RAW264.7 cells. The results showed that compounds 1 , 6 , 8, and 11 exhibited potent bioactivities by comparing with positive control. Then, compound 1 displayed the anti-inflammatory effect by inhibiting the MAPK/NF- κ B signaling pathways. Molecular docking further revealed the possible mechanism of compound 1 interaction with ERK protein.
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معلومات مُعتمدة: U20A2001, 42276114 the financial support from the National Natural Science Foundation of China; 2022AH050706 the Key Scientific Research Project in Colleges and the Universities of Anhui Province; 2308085QH302 the Natural Science Foundation of Anhui Province
فهرسة مساهمة: Keywords: Phomopsis sp.; anti-inflammatory; cytosporone; mangrove endophytic fungus
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20231225
رمز التحديث: 20231225
مُعرف محوري في PubMed: PMC10745014
DOI: 10.3390/md21120631
PMID: 38132952
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md21120631