دورية أكاديمية
Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus Phomopsis sp. QYM-13.
العنوان: | Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus Phomopsis sp. QYM-13. |
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المؤلفون: | Wang G; School of Pharmacy, Anhui Medical University, Hefei 230032, China.; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China., Yuan Y; National R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China., Li Z; School of Pharmacy, Anhui Medical University, Hefei 230032, China., Zhu J; School of Pharmacy, Anhui Medical University, Hefei 230032, China., She Z; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China., Chen Y; School of Pharmacy, Anhui Medical University, Hefei 230032, China. |
المصدر: | Marine drugs [Mar Drugs] 2023 Dec 07; Vol. 21 (12). Date of Electronic Publication: 2023 Dec 07. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2003]- |
مواضيع طبية MeSH: | Phomopsis* , Fungi*, Molecular Docking Simulation ; Anti-Inflammatory Agents/pharmacology ; Signal Transduction ; Molecular Structure |
مستخلص: | Six previously undescribed cytosporone derivatives (phomotones A-E ( 1 - 5 ) and phomotone F ( 13 )), two new spiro-alkanol phombistenes A-B ( 14 - 15 ), and seven known analogs ( 6 - 12 ) were isolated from the mangrove endophytic fungus Phomopsis sp. QYM-13. The structures of these compounds were elucidated using spectroscopic data analysis, electronic circular dichroism (ECD), and 13 C NMR calculations. Compound 14 features an unprecedented 1,6-dioxaspiro[4.5]decane ring system. All isolates were evaluated for their inhibitory effect on nitric oxide (NO) in LPS-induced RAW264.7 cells. The results showed that compounds 1 , 6 , 8, and 11 exhibited potent bioactivities by comparing with positive control. Then, compound 1 displayed the anti-inflammatory effect by inhibiting the MAPK/NF- κ B signaling pathways. Molecular docking further revealed the possible mechanism of compound 1 interaction with ERK protein. |
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معلومات مُعتمدة: | U20A2001, 42276114 the financial support from the National Natural Science Foundation of China; 2022AH050706 the Key Scientific Research Project in Colleges and the Universities of Anhui Province; 2308085QH302 the Natural Science Foundation of Anhui Province |
فهرسة مساهمة: | Keywords: Phomopsis sp.; anti-inflammatory; cytosporone; mangrove endophytic fungus |
المشرفين على المادة: | 0 (Anti-Inflammatory Agents) |
تواريخ الأحداث: | Date Created: 20231222 Date Completed: 20231225 Latest Revision: 20231225 |
رمز التحديث: | 20231225 |
مُعرف محوري في PubMed: | PMC10745014 |
DOI: | 10.3390/md21120631 |
PMID: | 38132952 |
قاعدة البيانات: | MEDLINE |
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