دورية أكاديمية
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D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning.

التفاصيل البيبلوغرافية
العنوان: D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning.
المؤلفون: Zachry JE; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Kutlu MG; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Yoon HJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Leonard MZ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Chevée M; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Patel DD; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Gaidici A; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Kondev V; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Thibeault KC; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Bethi R; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Tat J; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Melugin PR; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Isiktas AU; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Neuroscience, Yale University, New Haven, CT 06520, USA., Joffe ME; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219, USA., Cai DJ; Nash Family Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA., Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA., Grueter BA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Calipari ES; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: erin.calipari@vanderbilt.edu.
المصدر: Neuron [Neuron] 2024 Mar 06; Vol. 112 (5), pp. 835-849.e7. Date of Electronic Publication: 2023 Dec 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, Mass. : Cell Press, c1988-
مواضيع طبية MeSH: Receptors, Dopamine D1*/metabolism , Medium Spiny Neurons*, Mice ; Animals ; Mice, Transgenic ; Nucleus Accumbens/physiology ; Neurons/physiology ; Mice, Inbred C57BL
مستخلص: At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have opposing valence-based roles in behavior. Using optical imaging and manipulation approaches in mice, we show that neither D1 nor D2 MSNs signal valence. D1 MSN responses were evoked by stimuli regardless of valence or contingency. D2 MSNs were evoked by both cues and outcomes, were dynamically changed with learning, and tracked valence-free prediction error at the population and individual neuron level. Finally, D2 MSN responses to cues were necessary for associative learning. Thus, D1 and D2 MSNs work in tandem, rather than in opposition, by signaling specific properties of stimuli to control learning.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
References: Neuron. 2017 Oct 11;96(2):267-284. (PMID: 29024654)
Nature. 2014 May 22;509(7501):459-64. (PMID: 24848058)
J Neurosci. 2012 Oct 17;32(42):14804-8. (PMID: 23077064)
Curr Biol. 2021 Nov 8;31(21):4748-4761.e8. (PMID: 34529938)
Cell. 2015 Jul 30;162(3):635-47. (PMID: 26232229)
Behav Neurosci. 2015 Aug;129(4):450-6. (PMID: 26098230)
J Neurosci. 2016 Jan 27;36(4):1128-39. (PMID: 26818502)
Neuroscience. 2008 Jun 26;154(3):877-84. (PMID: 18479836)
Science. 1990 Dec 7;250(4986):1429-32. (PMID: 2147780)
Trends Neurosci. 1989 Oct;12(10):366-75. (PMID: 2479133)
Psychol Bull. 1973 Jun;79(6):398-407. (PMID: 4575029)
Nature. 2011 Jun 29;475(7356):377-80. (PMID: 21716290)
Nature. 2018 May;557(7704):177-182. (PMID: 29720658)
Nat Neurosci. 2013 May;16(5):632-8. (PMID: 23542690)
Nat Commun. 2022 Oct 21;13(1):6244. (PMID: 36271048)
Neuropsychopharmacology. 2018 Nov;43(12):2383-2389. (PMID: 29982266)
Nature. 2010 Jul 29;466(7306):622-6. (PMID: 20613723)
J Neurosci. 2011 Sep 14;31(37):13180-90. (PMID: 21917801)
Neuron. 2005 Feb 17;45(4):587-97. (PMID: 15721244)
Nat Neurosci. 2009 Apr;12(4):393-5. (PMID: 19270687)
Neuropharmacology. 2009;56 Suppl 1:122-32. (PMID: 18675281)
Neurosci Biobehav Rev. 2016 Sep;68:370-386. (PMID: 27235078)
Curr Biol. 2018 May 7;28(9):1392-1404.e5. (PMID: 29681476)
Psychopharmacology (Berl). 2007 Apr;191(3):521-50. (PMID: 16983543)
Science. 2004 Dec 10;306(5703):1944-7. (PMID: 15591205)
Brain Res. 2019 Jun 15;1713:1-15. (PMID: 30580012)
Sci Rep. 2018 Sep 26;8(1):14413. (PMID: 30258218)
PLoS One. 2018 Nov 29;13(11):e0207694. (PMID: 30496206)
Nat Neurosci. 2012 Jun;15(6):816-8. (PMID: 22544310)
Psychol Rep. 1973 Jun;32(3):1247-52. (PMID: 4709821)
Nat Methods. 2009 Dec;6(12):875-81. (PMID: 19898485)
Biol Psychiatry. 2015 Feb 1;77(3):212-222. (PMID: 25173629)
Nat Neurosci. 2015 Sep;18(9):1230-2. (PMID: 26214370)
Nat Commun. 2018 Mar 14;9(1):1086. (PMID: 29540712)
Curr Biol. 1997 Dec 1;7(12):R768-9. (PMID: 9382820)
Annu Rev Neurosci. 1992;15:285-320. (PMID: 1575444)
Nature. 2017 Mar 2;543(7643):103-107. (PMID: 28225752)
Neuron. 2016 Jun 1;90(5):1100-13. (PMID: 27181061)
Neuropsychopharmacology. 2014 Jan;39(2):254-62. (PMID: 24121188)
Neuron. 2016 Oct 5;92(1):214-226. (PMID: 27667004)
Neuron. 2016 Jan 20;89(2):285-99. (PMID: 26774160)
Neurol Sci. 2004 Jun;25(2):98-101. (PMID: 15221629)
Science. 2005 Mar 11;307(5715):1642-5. (PMID: 15761155)
Nat Commun. 2016 Jun 23;7:11829. (PMID: 27337658)
J Neurosci. 2012 Oct 3;32(40):13819-40. (PMID: 23035093)
Biol Psychiatry. 2014 May 15;75(10):807-816. (PMID: 24143880)
Elife. 2023 Mar 22;12:. (PMID: 36946371)
Neural Netw. 2006 Oct;19(8):1277-301. (PMID: 16938431)
Cell Rep. 2023 Feb 28;42(2):112069. (PMID: 36753418)
Neuron. 2015 Sep 2;87(5):1063-77. (PMID: 26335648)
Arch Neurol. 2005 Sep;62(9):1377-81. (PMID: 16009751)
J Neurosci. 2001 May 1;21(9):3251-60. (PMID: 11312310)
Neuropsychopharmacology. 2020 Aug;45(9):1463-1472. (PMID: 32375157)
Cell Rep. 2022 Feb 15;38(7):110380. (PMID: 35172164)
J Neurosci. 2017 Jan 25;37(4):757-767. (PMID: 28123013)
Nat Rev Neurosci. 2013 Sep;14(9):609-25. (PMID: 23942470)
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14845-50. (PMID: 20682746)
Neuron. 2015 Oct 21;88(2):247-63. (PMID: 26494275)
Psychol Bull. 2004 Sep;130(5):769-92. (PMID: 15367080)
Neuron. 2019 Jan 2;101(1):133-151.e7. (PMID: 30503173)
Neurosci Biobehav Rev. 2021 Apr;123:337-351. (PMID: 33453307)
Trends Pharmacol Sci. 2018 Mar;39(3):276-294. (PMID: 29338873)
Neuron. 2011 Feb 24;69(4):603-17. (PMID: 21338874)
Neuroscientist. 2007 Apr;13(2):148-59. (PMID: 17404375)
Nat Neurosci. 2014 Sep;17(9):1198-207. (PMID: 25108911)
Front Neural Circuits. 2020 Jun 30;14:37. (PMID: 32694984)
Psychol Rev. 2003 Jan;110(1):145-72. (PMID: 12529060)
Science. 2003 Mar 21;299(5614):1898-902. (PMID: 12649484)
eNeuro. 2018 May 16;5(2):. (PMID: 29780881)
Neuron. 2012 Nov 21;76(4):790-803. (PMID: 23177963)
J Neurosci. 2020 Jun 10;40(24):4750-4760. (PMID: 32381486)
Science. 2010 Oct 15;330(6002):385-90. (PMID: 20947769)
Elife. 2018 Feb 22;7:. (PMID: 29469809)
Nature. 2016 Mar 31;531(7596):642-6. (PMID: 27007845)
PLoS One. 2015 Apr 01;10(4):e0123381. (PMID: 25830919)
Nat Methods. 2019 Jul;16(7):649-657. (PMID: 31209382)
J Neurosci. 2011 May 4;31(18):6820-30. (PMID: 21543612)
Nat Neurosci. 2022 Aug;25(8):1071-1081. (PMID: 35902648)
Mol Psychiatry. 2020 Dec;25(12):3241-3255. (PMID: 31462765)
Science. 1997 Mar 14;275(5306):1593-9. (PMID: 9054347)
Nat Commun. 2022 Mar 22;13(1):1541. (PMID: 35318343)
Front Neuroanat. 2011 Jul 18;5:41. (PMID: 21811439)
J Neurosci. 2017 Mar 8;37(10):2723-2733. (PMID: 28167674)
Nature. 2022 Nov;611(7934):124-132. (PMID: 36261520)
Psychopharmacology (Berl). 2007 Apr;191(3):439-59. (PMID: 17318502)
Behav Processes. 2011 Feb;86(2):242-9. (PMID: 21193021)
Biol Psychiatry. 2016 Nov 1;80(9):671-681. (PMID: 27209241)
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6455-60. (PMID: 24737889)
Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2726-31. (PMID: 26831103)
معلومات مُعتمدة: T32 GM007628 United States GM NIGMS NIH HHS; KL2 TR002245 United States TR NCATS NIH HHS; DP1 DA048931 United States DA NIDA NIH HHS; T32 MH065215 United States MH NIMH NIH HHS; R21 MH132052 United States MH NIMH NIH HHS; R00 DA042111 United States DA NIDA NIH HHS; R01 AA030931 United States AA NIAAA NIH HHS; P50 HD103537 United States HD NICHD NIH HHS; R01 DA052317 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: aversion; calcium imaging; fear conditioning; motivation; reinforcement learning; striatum
المشرفين على المادة: 0 (Receptors, Dopamine D1)
تواريخ الأحداث: Date Created: 20231222 Date Completed: 20240311 Latest Revision: 20240501
رمز التحديث: 20240501
مُعرف محوري في PubMed: PMC10939818
DOI: 10.1016/j.neuron.2023.11.023
PMID: 38134921
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4199
DOI:10.1016/j.neuron.2023.11.023