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Antimicrobial Potential of Different Isolates of Chaetomium globosum Combined with Liquid Chromatography Tandem Mass Spectrometry Chemical Profiling.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial Potential of Different Isolates of Chaetomium globosum Combined with Liquid Chromatography Tandem Mass Spectrometry Chemical Profiling.
المؤلفون: Goda MS; Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt., El-Kattan N; Department of Microbiology, Research Institute of Medical Entomology, General Organization for Teaching Hospitals and Institutes, Giza 11562, Egypt., Abdel-Azeem MA; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, Al-Arish, North Sinai 45511, Egypt., Allam KAM; Department of Epidemiology, Research Institute of Medical Entomology, General Organization for Teaching Hospitals and Institutes, Giza 11562, Egypt., Badr JM; Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt., Nassar NA; Department of Clinical Pathology, Al-Sahel Teaching Hospital, Cairo 11697, Egypt., Almalki AJ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alharbi M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Elhady SS; Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Eltamany EE; Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
المصدر: Biomolecules [Biomolecules] 2023 Nov 21; Vol. 13 (12). Date of Electronic Publication: 2023 Nov 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2011-
مواضيع طبية MeSH: Chaetomium*/chemistry , Anti-Infective Agents*/metabolism, Chromatography, Liquid ; Tandem Mass Spectrometry ; Anti-Bacterial Agents/chemistry ; Bacteria/metabolism ; Microbial Sensitivity Tests ; Soil
مستخلص: The antimicrobial resistance of pathogenic microorganisms against commercial drugs has become a major problem worldwide. This study is the first of its kind to be carried out in Egypt to produce antimicrobial pharmaceuticals from isolated native taxa of the fungal Chaetomium , followed by a chemical investigation of the existing bioactive metabolites. Here, of the 155 clinical specimens in total, 100 pathogenic microbial isolates were found to be multi-drug resistant (MDR) bacteria. The Chaetomium isolates were recovered from different soil samples, and wild host plants collected from Egypt showed strong inhibitory activity against MDR isolates. Chaetomium isolates displayed broad-spectrum antimicrobial activity against C. albicans, Gram-positive, and Gram-negative bacteria, with inhibition zones of 11.3 to 25.6 mm, 10.4 to 26.0 mm, and 10.5 to 26.5 mm, respectively. As a consecutive result, the minimum inhibitory concentration (MIC) values of Chaetomium isolates ranged from 3.9 to 62.5 µg/mL. Liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) analysis was performed for selected Chaetomium isolates with the most promising antimicrobial potential against MDR bacteria. The LC-MS/MS analysis of Chaetomium species isolated from cultivated soil at Assuit Governate, Upper Egypt ( 3 ), and the host plant Zygophyllum album grown in Wadi El-Arbaein, Saint Katherine, South Sinai ( 5 ), revealed the presence of alkaloids as the predominant bioactive metabolites. Most detected bioactive metabolites previously displayed antimicrobial activity, confirming the antibacterial potential of selected isolates. Therefore, the Chaetomium isolates recovered from harsh habitats in Egypt are rich sources of antimicrobial metabolites, which will be a possible solution to the multi-drug resistant bacteria tragedy.
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فهرسة مساهمة: Keywords: Chaetomium; LC-MS/MS; MDR; MIC; antimicrobial; drug discovery; public health
المشرفين على المادة: 0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
0 (Soil)
SCR Organism: Chaetomium globosum
تواريخ الأحداث: Date Created: 20231223 Date Completed: 20231225 Latest Revision: 20240104
رمز التحديث: 20240104
مُعرف محوري في PubMed: PMC10742071
DOI: 10.3390/biom13121683
PMID: 38136556
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-273X
DOI:10.3390/biom13121683