دورية أكاديمية
Antibody Response to SARS-CoV-2 Vaccination in Patients with End-Stage Kidney Disease on Hemodialysis.
| العنوان: | Antibody Response to SARS-CoV-2 Vaccination in Patients with End-Stage Kidney Disease on Hemodialysis. |
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| المؤلفون: | Andhika R; Division of Nephrology and Hypertension, Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Anand MI; Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Tiara MR; Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjajaran, Bandung 40161, Indonesia., Debora J; Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Djauhari H; Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjajaran, Bandung 40161, Indonesia., Susandi E; Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Mareta A; Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjajaran, Bandung 40161, Indonesia., Riswoko A; Research Center for Polymer Technology-National Research and Innovation Agency (BRIN), Jakarta 10340, Indonesia., Susilawati N; Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjajaran, Bandung 40161, Indonesia., Indrati AR; Department of Clinical Pathology, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Alisjahbana B; Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas Padjajaran, Bandung 40161, Indonesia.; Division of Tropical and Infectious Diseases, Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia., Supriyadi R; Division of Nephrology and Hypertension, Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia. |
| المصدر: | Vaccines [Vaccines (Basel)] 2023 Dec 01; Vol. 11 (12). Date of Electronic Publication: 2023 Dec 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG |
| مستخلص: | Patients with end-stage kidney disease on hemodialysis (ESKD-HD) have a high risk of contracting severe COVID-19. Vaccination can help reduce disease severity, but the immune dysregulation observed in these patients may result in an inadequate antibody response. Therefore, we aimed to evaluate the immune response postvaccination in ESKD-HD patients. This prospective cohort study was conducted in two hemodialysis centers in Indonesia. We enrolled ESKD-HD patients ( n = 143) pre- and postvaccination and compared them to healthy subjects ( n = 67). SARS-CoV-2 antibody response was assessed using anti-S-RBD antibodies and SVNT % inhibition tests. We performed bivariate and multivariate analysis to determine factors associated with SARS-CoV-2 antibody levels. Seropositive conversion was observed in 97% ESKD-HD subjects postvaccination. Compared with healthy subjects, ESKD-HD patients showed a comparable anti-S-RBD antibody titer postvaccination. mRNA vaccines remained a significant factor for the high immune response, while hypoalbuminemia correlated with lower immune response. In conclusion, ESKD-HD patients showed a robust immune response postvaccination. mRNA vaccines induced a stronger antibody response than other vaccines. Lower levels of serum albumin correlate with lower immune responses in ESKD-HD patients after vaccination. |
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| فهرسة مساهمة: | Keywords: COVID-19; antibody level; chronic kidney disease; vaccination |
| تواريخ الأحداث: | Date Created: 20231223 Latest Revision: 20231225 |
| رمز التحديث: | 20231225 |
| مُعرف محوري في PubMed: | PMC10747993 |
| DOI: | 10.3390/vaccines11121802 |
| PMID: | 38140206 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2076-393X |
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| DOI: | 10.3390/vaccines11121802 |