دورية أكاديمية
A lipidomic and metabolomic signature of a very low-carbohydrate high-fat diet and high-intensity interval training: an additional analysis of a randomized controlled clinical trial.
| العنوان: | A lipidomic and metabolomic signature of a very low-carbohydrate high-fat diet and high-intensity interval training: an additional analysis of a randomized controlled clinical trial. |
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| المؤلفون: | Cipryan L; Department of Human Movement Studies and Human Motion Diagnostic Centre, The University of Ostrava, Ostrava, Czech Republic., Kosek V; Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 16628, Prague, Czech Republic. Vit.Kosek@vscht.cz., García CJ; Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 16628, Prague, Czech Republic., Dostal T; Department of Human Movement Studies and Human Motion Diagnostic Centre, The University of Ostrava, Ostrava, Czech Republic., Bechynska K; Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 16628, Prague, Czech Republic., Hajslova J; Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 16628, Prague, Czech Republic., Hofmann P; Institute of Human Movement Science, Sport and Health, Exercise Physiology, Training and Training Therapy Research Group, University of Graz, Graz, Austria. |
| المصدر: | Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2023 Dec 23; Vol. 20 (1), pp. 10. Date of Electronic Publication: 2023 Dec 23. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer, c2006- |
| مواضيع طبية MeSH: | Lipidomics* , High-Intensity Interval Training*, Humans ; Diet, High-Fat ; Metabolomics ; Triglycerides ; Carbohydrates |
| مستخلص: | Introduction: Regular physical activity and dietary variety are modifiable and influential factors of health outcomes. However, the cumulative effects of these behaviors are not well understood. Metabolomics may have a promising research potential to extend our knowledge and use it in the attempts to find a long-term and sustainable personalized approach in exercise and diet recommendations. Objective: The main aim was to investigate the effect of the 12 week very low carbohydrate high fat (VLCHF) diet and high-intensity interval training (HIIT) on lipidomic and metabolomic profiles in individuals with overweight and obesity. Methods: The participants (N = 91) were randomly allocated to HIIT (N = 22), VLCHF (N = 25), VLCHF + HIIT (N = 25) or control (N = 19) groups for 12 weeks. Fasting plasma samples were collected before the intervention and after 4, 8 and 12 weeks. The samples were then subjected to untargeted lipidomic and metabolomic analyses using reversed phase ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry. Results: The VLCHF diet affected plasma lipids considerably while the effect of HIIT was unremarkable. Already after 4 weeks of intervention substantial changes of plasma lipids were found in both VLCHF diet groups. The changes persisted throughout the entire 12 weeks of the VLCHF diet. Specifically, acyl carnitines, plasmalogens, fatty acyl esters of hydroxy fatty acid, sphingomyelin, ceramides, cholesterol esters, fatty acids and 4-hydroxybutyric were identified as lipid families that increased in the VLCHF diet groups whereas lipid families of triglycerides and glycerophospholipids decreased. Additionally, metabolomic analysis showed a decrease of theobromine. Conclusions: This study deciphers the specific responses to a VLCHF diet, HIIT and their combination by analysing untargeted lipidomic and metabolomic profile. VLCHF diet caused divergent changes of plasma lipids and other metabolites when compared to the exercise and control group which may contribute to a better understanding of metabolic changes and the appraisal of VLCHF diet benefits and harms. Clinical Trial Registry Number: NCT03934476, registered 1st May 2019 https://clinicaltrials.gov/ct2/show/NCT03934476?term=NCT03934476&draw=2&rank=1 . (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | 18-08358S Grantová Agentura České Republiky; 18-08358S Grantová Agentura České Republiky; CZ.02.1.01/0.0/0.0/16_019/0000798 Ministerstvo Školství, Mládeže a Tělovýchovy; CZ.02.1.01/0.0/0.0/16_019/0000798 Ministerstvo Školství, Mládeže a Tělovýchovy |
| فهرسة مساهمة: | Keywords: Carbohydrates; Diet; Exercise; Lipidomics; Lipids; Metabolomics |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03934476 |
| المشرفين على المادة: | 0 (Triglycerides) 0 (Carbohydrates) |
| تواريخ الأحداث: | Date Created: 20231223 Date Completed: 20231225 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| DOI: | 10.1007/s11306-023-02071-1 |
| PMID: | 38141101 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-3890 |
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| DOI: | 10.1007/s11306-023-02071-1 |