دورية أكاديمية
Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors.
| العنوان: | Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. |
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| المؤلفون: | Nasr Z; UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. Electronic address: emmanuelle.waubant@ucsf.edu., Virupakshaiah A; UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Schoeps VA; UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Cherbuin N; Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia., Casper TC; University of Utah School of Medicine, Salt Lake City, Utah, USA., Waltz M; University of Utah School of Medicine, Salt Lake City, Utah, USA., Hart J; UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Rodriguez M; Mayo Clinic, Rochester, Minnesota, USA., Gorman MP; Boston Childrens Hospital, Boston, Massachusetts, USA., Benson LA; Boston Childrens Hospital, Boston, Massachusetts, USA., Chitnis T; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rensel M; Cleveland Clinic, Cleveland, Ohio, USA., Abrams A; Cleveland Clinic, Cleveland, Ohio, USA., Krupp L; New York University Medical Center, New York City, New York, USA., Waldman AT; Division of Child Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lotze T; Texas Children's Hospital, Houston, Texas, USA., Aaen GS; Loma Linda University Children's Hospital, Loma Linda, California, USA., Mar S; Washington University in St. Louis, St Louis, Missouri, USA., Schreiner T; Childrens Hospital Colorado/University of Colorado, Aurora, Colorado, USA., Wheeler Y; Children's Hospital of Alabama, Birmingham, Alabama, USA., Rose J; George E. Wahlen Department of Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT, USA., Shukla NM; Baylor College of Medicine/Texas Children's Hospital, Neurology and Developmental Neuroscience, Houston, Texas, USA., Barcellos LF; Genetic Epidemiology and Genomics Laboratory, Divisions of Epidemiology and Biostatistics, School of Public Health, University of California Berkeley, Berkeley, California, USA., Lucas R; National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia., Waubant E; UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. |
| المصدر: | Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2024 Feb; Vol. 82, pp. 105351. Date of Electronic Publication: 2023 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101580247 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-0356 (Electronic) Linking ISSN: 22110348 NLM ISO Abbreviation: Mult Scler Relat Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B. V. |
| مواضيع طبية MeSH: | Gene-Environment Interaction* , Multiple Sclerosis*/etiology , Multiple Sclerosis*/genetics, Child ; Humans ; Case-Control Studies ; Ultraviolet Rays/adverse effects ; Risk Factors |
| مستخلص: | Background: Our previous study identified a significant association between lower time spent outdoors, as a proxy of sun exposure, and a higher risk of pediatric-onset multiple sclerosis (POMS). UV radiation modulates the expression of several genes, but it is unknown whether these genes modify the effect of sun exposure on POMS risk. Methods: In an age- and sex-matched case-control study, we evaluated the additive and multiplicative interactions between time spent outdoors and genetic non-HLA risk variants for developing POMS within the metabolic pathways of UV radiation, including CD28(rs6435203), CD86(rs9282641), and NFkB1(rs7665090) and the top two HLA risk factors (presence of DRB1×15 and absence of A*02). Results: In an adjusted model (332 POMS cases, 534 healthy controls), greater time compared to <30 min/day spent outdoors during the prior summer and higher UV radiation dose were associated with decreased odds of POMS (OR 0.66, 95% CI 0.56-0.78, p < 0.001; OR 0.78, 95 % CI 0.62-0.98, p = 0.04, respectively). No significant additive or multiplicative interactions were found between risk factors. Conclusions: The exploration of gene-environment interactions in the risk of developing MS can unravel the underlying mechanisms involved. Although we do not have evidence that our candidate genes contribute to interactions, other genes may. Competing Interests: Declaration of Competing Interest There is no conflict of interest related to this paper. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Gene-environment interactions; Multiple sclerosis; Risk factors; Time spent outdoors |
| تواريخ الأحداث: | Date Created: 20231223 Date Completed: 20240205 Latest Revision: 20240205 |
| رمز التحديث: | 20240205 |
| DOI: | 10.1016/j.msard.2023.105351 |
| PMID: | 38141560 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2211-0356 |
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| DOI: | 10.1016/j.msard.2023.105351 |