دورية أكاديمية
A new benzophenanthridine alkaloid from stem bark of Zanthoxylum rhetsa and its biological activities.
| العنوان: | A new benzophenanthridine alkaloid from stem bark of Zanthoxylum rhetsa and its biological activities. |
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| المؤلفون: | Nguyen THV; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.; Graduate University of Science and Techology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Tran TT; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Do HN; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.; Graduate University of Science and Techology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Quan PM; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.; Graduate University of Science and Techology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Pham CB; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Dang HH; University of Science and Technology of Hanoi, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Lam DT; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam., Minh PTH; Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.; Graduate University of Science and Techology, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam. |
| المصدر: | Natural product research [Nat Prod Res] 2023 Dec 25, pp. 1-13. Date of Electronic Publication: 2023 Dec 25. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: | A new benzophenanthridine alkaloid 6-butanoyldihydrochelerythrine (1) and five known alkaloids 6-acetonyldihydronitidine (2) , 6-acetonyldihydrochelerythrine (3) , isocorydine (4) , (O)-methyltembamide (5) , N-(4-methoxyphenethyl)benzamide (6) were isolated from the stem barks of Zanthoxylum rhetsa . These structures were elucidated by 1D, 2D NMR spectroscopy and by mass spectrometry. This is the first time that compounds 2-6 were identified from Zanthoxylum rhetsa and the first time that compounds 4 and 6 were identified from the genus Zanthoxylum . Bioactivity results of isolated compounds showed that 1 , 2 , 5 and 6 exhibited inhibitory activity against MCF7 and A549 cell lines, while 3 showed the inhibitory activity against A549 cell line; all isolated compounds 1 - 6 inhibited at least two strain microorganisms; compound 4 showed angiotensin II converting enzyme inhibitory activity in vitro with IC |
| فهرسة مساهمة: | Keywords: 6-butanoyldihydrochelerythrine; ACE2-inhibiting activity; Zanthoxylum rhetsa; antimicrobial; cytotoxic; in silico; in vitro |
| تواريخ الأحداث: | Date Created: 20231226 Latest Revision: 20231226 |
| رمز التحديث: | 20231227 |
| DOI: | 10.1080/14786419.2023.2297261 |
| PMID: | 38146230 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2297261 |