دورية أكاديمية
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis.
العنوان: | Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis. |
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المؤلفون: | Di Florio DN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Macomb LP; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Giresi PG; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Beetler DJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Bonvie-Hill NE; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Shapiro KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Naser AN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Khatib S; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Whelan ER; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Weigel GJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Edenfield BH; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Balamurugan V; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Burris SK; Fujifilm VisualSonics Inc, Toronto, ON, Canada., Rich LJ; Fujifilm VisualSonics Inc, Toronto, ON, Canada., Bruno KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA., Cooper LT Jr; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., McLeod CJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Yamani MH; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Fairweather D; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Jacksonville, FL, USA.; Department of Medicine, Mayo Clinic, Jacksonville, FL, USA. |
المصدر: | IScience [iScience] 2023 Nov 20; Vol. 26 (12), pp. 108493. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
مستخلص: | Myocarditis is typically caused by viral infections, but most cases are thought to be subclinical. Echocardiography is often used for initial assessment of myocarditis patients but is poor at detecting subtle changes in cardiac dysfunction. Cardiac strain, such as global longitudinal strain (GLS) and global circumferential strain (GCS), represents an increasingly used set of measurements which can detect these subtle changes. Using a murine model of coxsackievirus B3 myocarditis, we characterized functional changes in the heart using echocardiography during myocarditis and by sex. We found that 2D GLS, 4D mode, and 4D strains detected a significant reduction in ejection fraction and GLS during myocarditis compared to baseline and in males compared to females. Furthermore, worse GLS correlated to increased levels of CD45 + , CD11b+, and CD3 + immune cells. Our findings closely resemble published reports of GLS in patients with myocarditis indicating the usefulness of this animal model for translational studies of myocarditis. Competing Interests: The authors declare no conflict of interest. (© 2023 The Authors.) |
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معلومات مُعتمدة: | R21 AI163302 United States AI NIAID NIH HHS; R01 HL135165 United States HL NHLBI NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS; UL1 TR002377 United States TR NCATS NIH HHS; R21 AI154927 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Biological sciences; Cardiovascular medicine; Physiology |
سلسلة جزيئية: | Dryad 10.5061/dryad.mcvdnck6f |
تواريخ الأحداث: | Date Created: 20231226 Latest Revision: 20240210 |
رمز التحديث: | 20240210 |
مُعرف محوري في PubMed: | PMC10749256 |
DOI: | 10.1016/j.isci.2023.108493 |
PMID: | 38146431 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2589-0042 |
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DOI: | 10.1016/j.isci.2023.108493 |