دورية أكاديمية
أعرض في EDS

Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis.

التفاصيل البيبلوغرافية
العنوان: Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis.
المؤلفون: Di Florio DN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Macomb LP; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Giresi PG; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Beetler DJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Bonvie-Hill NE; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Shapiro KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Naser AN; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Khatib S; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Whelan ER; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Weigel GJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Edenfield BH; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Balamurugan V; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Burris SK; Fujifilm VisualSonics Inc, Toronto, ON, Canada., Rich LJ; Fujifilm VisualSonics Inc, Toronto, ON, Canada., Bruno KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA., Cooper LT Jr; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., McLeod CJ; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Yamani MH; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA., Fairweather D; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Jacksonville, FL, USA.; Department of Medicine, Mayo Clinic, Jacksonville, FL, USA.
المصدر: IScience [iScience] 2023 Nov 20; Vol. 26 (12), pp. 108493. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Myocarditis is typically caused by viral infections, but most cases are thought to be subclinical. Echocardiography is often used for initial assessment of myocarditis patients but is poor at detecting subtle changes in cardiac dysfunction. Cardiac strain, such as global longitudinal strain (GLS) and global circumferential strain (GCS), represents an increasingly used set of measurements which can detect these subtle changes. Using a murine model of coxsackievirus B3 myocarditis, we characterized functional changes in the heart using echocardiography during myocarditis and by sex. We found that 2D GLS, 4D mode, and 4D strains detected a significant reduction in ejection fraction and GLS during myocarditis compared to baseline and in males compared to females. Furthermore, worse GLS correlated to increased levels of CD45 + , CD11b+, and CD3 + immune cells. Our findings closely resemble published reports of GLS in patients with myocarditis indicating the usefulness of this animal model for translational studies of myocarditis.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors.)
References: Clin Sci (Lond). 2003 Jun;104(6):577-84. (PMID: 12589705)
J Immunol. 2007 Jun 1;178(11):6710-4. (PMID: 17513715)
Circulation. 2010 Oct 5;122(14):1396-404. (PMID: 20855659)
Circulation. 2013 Aug 6;128(6):643-52; discussion 652. (PMID: 23918185)
Heart Lung Circ. 2019 Sep;28(9):1400-1410. (PMID: 31047786)
J Appl Physiol (1985). 2006 Aug;101(2):460-8. (PMID: 16601310)
Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H197-H207. (PMID: 34085843)
J Am Heart Assoc. 2022 Oct 4;11(19):e025106. (PMID: 36129042)
Eur Radiol. 2022 May;32(5):3436-3446. (PMID: 34932165)
N Engl J Med. 2021 May 27;384(21):2014-2027. (PMID: 34042389)
J Cardiovasc Transl Res. 2014 Mar;7(2):192-202. (PMID: 24402571)
Clin Exp Immunol. 2019 Oct;198(1):101-110. (PMID: 31099056)
Curr Protoc Immunol. 2013;Chapter 15:Unit 15.14.1-51. (PMID: 23564686)
Circ Cardiovasc Imaging. 2021 Jan;14(1):e012220. (PMID: 33463366)
Circulation. 1996 Mar 1;93(5):841-2. (PMID: 8598070)
Radiol Cardiothorac Imaging. 2022 Jun 09;4(3):e210318. (PMID: 35833169)
ESC Heart Fail. 2022 Apr;9(2):925-941. (PMID: 35178861)
J Cardiovasc Magn Reson. 2021 Sep 9;23(1):101. (PMID: 34496880)
J Clin Med. 2021 Oct 12;10(20):. (PMID: 34682794)
Brain Res. 2006 Dec 18;1126(1):139-47. (PMID: 16949558)
Eur J Heart Fail. 2022 Nov;24(11):2000-2018. (PMID: 36065751)
J Cardiovasc Transl Res. 2020 Oct;13(5):853-863. (PMID: 32006209)
J Immunol. 2003 May 1;170(9):4731-7. (PMID: 12707353)
Heart Lung Circ. 2020 Aug;29(8):1139-1145. (PMID: 32094080)
J Autoimmun. 2001 May;16(3):175-86. (PMID: 11334481)
Curr Probl Cardiol. 2013 Jan;38(1):7-46. (PMID: 23158412)
Lab Invest. 2004 Feb;84(2):173-81. (PMID: 14688801)
J Am Coll Cardiol. 2020 Feb 11;75(5):467-478. (PMID: 32029128)
Appl Sci (Basel). 2021 Feb 2;11(4):. (PMID: 34306738)
JCI Insight. 2016 Jun 16;1(9):. (PMID: 27366791)
J Am Heart Assoc. 2019 Jan 22;8(2):e008968. (PMID: 30638108)
Front Cardiovasc Med. 2023 Jan 18;9:1073814. (PMID: 36741845)
Circ Arrhythm Electrophysiol. 2014 Apr;7(2):205-11. (PMID: 24604905)
Front Cardiovasc Med. 2023 Mar 02;10:1129348. (PMID: 36937911)
J Immunol. 2006 Mar 15;176(6):3516-24. (PMID: 16517720)
Magn Reson Imaging. 2020 Nov;73:62-69. (PMID: 32853757)
Heart. 2013 Nov;99(22):1681-4. (PMID: 24064227)
Heart Fail Clin. 2010 Jan;6(1):75-85. (PMID: 19945063)
Rofo. 2018 Aug;190(8):722-732. (PMID: 30045397)
Forensic Sci Res. 2019 Aug 19;4(3):247-256. (PMID: 31489390)
Am J Physiol Regul Integr Comp Physiol. 2013 Feb 15;304(4):R267-77. (PMID: 23255589)
Nat Rev Cardiol. 2021 Mar;18(3):169-193. (PMID: 33046850)
Am J Emerg Med. 2017 Feb;35(2):201-205. (PMID: 27836311)
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. (PMID: 33309175)
معلومات مُعتمدة: R21 AI163302 United States AI NIAID NIH HHS; R01 HL135165 United States HL NHLBI NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS; UL1 TR002377 United States TR NCATS NIH HHS; R21 AI154927 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Biological sciences; Cardiovascular medicine; Physiology
سلسلة جزيئية: Dryad 10.5061/dryad.mcvdnck6f
تواريخ الأحداث: Date Created: 20231226 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10749256
DOI: 10.1016/j.isci.2023.108493
PMID: 38146431
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2023.108493