دورية أكاديمية
Stress-Induced Graves Disease: Spontaneous Recovery After Stress Relief.
| العنوان: | Stress-Induced Graves Disease: Spontaneous Recovery After Stress Relief. |
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| المؤلفون: | Willems JIA; Department of Internal Medicine, Zuyd Thyroid Center, Zuyderland Medical Center, 6162 BG Sittard-Geleen, The Netherlands., van Twist DJL; Department of Internal Medicine, Zuyd Thyroid Center, Zuyderland Medical Center, 6162 BG Sittard-Geleen, The Netherlands., Peeters RP; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Mostard GJM; Department of Internal Medicine, Zuyd Thyroid Center, Zuyderland Medical Center, 6162 BG Sittard-Geleen, The Netherlands., van Wijngaarden RFATL; Department of Internal Medicine, Zuyd Thyroid Center, Zuyderland Medical Center, 6162 BG Sittard-Geleen, The Netherlands. |
| المصدر: | Journal of the Endocrine Society [J Endocr Soc] 2023 Dec 13; Vol. 8 (1), pp. bvad157. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : Endocrine Society, [2017]- |
| مستخلص: | Purpose: Emotional stress is a precipitating factor for Graves disease (GD). However, the influence of stress relief on the course of GD is unknown. Here, we present a series of patients diagnosed with stress-induced GD in whom stress relief alone led to remission of GD. Cases: We report on 11 patients in whom hyperthyroid symptoms started just after severe emotional stress. All patients had suppressed thyroid-stimulating hormone (TSH) levels and elevated free thyroxine (FT4; 22.2-49.5 pmol/L) and TSH-receptor antibody (TRAb; 0.57-40 U/L) levels and were subsequently diagnosed with stress-induced GD. However, all patients declined antithyroid drug treatment. Surprisingly, clinical and biochemical remission was observed in 9 out of 11 patients after 1 to 3 and 2 to 7 months of self-reported stress relief, respectively. Five patients showed long-lasting remission (median follow-up 2.3 years). In 4 patients, remission was initially achieved, but GD relapsed 1 to 4 years afterwards. In 2 patients, treatment with antithyroid drugs was initiated because of rapidly increasing FT4 levels. Baseline FT4 and TRAb levels tended to be higher in patients who did not achieve remission. Furthermore, patients without long-lasting remission were more frequently known to have prior thyroid disease. Conclusion: We report on a series of patients with stress-induced GD in whom stress relief alone led to remission of GD (thus without antithyroid drugs). This may indicate that clinicians could consider stopping antithyroid drug treatment or at least shortening the treatment period after stress relief in patients with stress-induced GD. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.) |
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| فهرسة مساهمة: | Keywords: Graves’ disease; remission; stress; stress relief |
| تواريخ الأحداث: | Date Created: 20231227 Latest Revision: 20231228 |
| رمز التحديث: | 20231228 |
| مُعرف محوري في PubMed: | PMC10750305 |
| DOI: | 10.1210/jendso/bvad157 |
| PMID: | 38148855 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2472-1972 |
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| DOI: | 10.1210/jendso/bvad157 |