دورية أكاديمية
[Advances in live-imaging aging reporter mice].
| العنوان: | [Advances in live-imaging aging reporter mice]. |
|---|---|
| المؤلفون: | Sun J; School of Basic Medical Science, Shenzhen University, Shenzhen 518060, China.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), Shenzhen 518060, China. jiesun_szu@126.com., Wang YN; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China., Luo SS; Luohu Clinical Institute of Shantou University Medical College, Shenzhen 518005, China., Liu BH; School of Basic Medical Science, Shenzhen University, Shenzhen 518060, China.; Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), Shenzhen 518060, China. ppliew@szu.edu.cn. |
| المصدر: | Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2023 Dec 25; Vol. 75 (6), pp. 836-846. |
| نوع المنشور: | Review; English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Science Press Original Publication: Beiping, 1953- |
| مواضيع طبية MeSH: | Aging* , Cyclin-Dependent Kinase Inhibitor p16*/metabolism, Humans ; Animals ; Mice ; Aged ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Biomarkers ; Tumor Suppressor Protein p53 |
| مستخلص: | Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16 Ink4a , p21 Waf1/Cip1 , p53 and Glb1), and discusses their applications in aging research. |
| المشرفين على المادة: | 0 (Cyclin-Dependent Kinase Inhibitor p16) 0 (Cyclin-Dependent Kinase Inhibitor p21) 0 (Biomarkers) 0 (Tumor Suppressor Protein p53) |
| تواريخ الأحداث: | Date Created: 20231227 Date Completed: 20231229 Latest Revision: 20231229 |
| رمز التحديث: | 20231229 |
| PMID: | 38151347 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0371-0874 |
|---|