دورية أكاديمية
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina.
العنوان: | Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina. |
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المؤلفون: | Ornelas IM; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Espírito Santo, 29047-105, Brazil., Silva TM; Department of Neurobiology, Neuroscience Program, Federal Fluminense University, Rua Prof. M.W. de Freitas Reis, bloco M, sala 409, São Domingos, Niterói, Rio de Janeiro, CEP 24210-201, Brazil., Pereira MR; Department of Neurobiology, Neuroscience Program, Federal Fluminense University, Rua Prof. M.W. de Freitas Reis, bloco M, sala 409, São Domingos, Niterói, Rio de Janeiro, CEP 24210-201, Brazil., França GR; Department of Physiological Sciences, Federal University of the State of Rio de Janeiro, Rua Frei Caneca 94, Centro, Rio de Janeiro, RJ, CEP 20211-040, Brazil., Ventura ALM; Department of Neurobiology, Neuroscience Program, Federal Fluminense University, Rua Prof. M.W. de Freitas Reis, bloco M, sala 409, São Domingos, Niterói, Rio de Janeiro, CEP 24210-201, Brazil. almvuff@gmail.com. |
المصدر: | Purinergic signalling [Purinergic Signal] 2023 Dec 27. Date of Electronic Publication: 2023 Dec 27. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 101250499 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-9546 (Electronic) Linking ISSN: 15739538 NLM ISO Abbreviation: Purinergic Signal Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Dordrecht, the Netherlands : Springer |
مستخلص: | In the avian retina, ADP induces the proliferation of late developing glia progenitors. Here, we show that in serum-containing retinal cell cultures, ADP-induced increase in [ 3 H]-thymidine incorporation can be prevented by the IGF-1 receptor antagonists AG1024 and I-OMe-Tyrphostin AG 538, suggesting the participation of IGF-1 in ADP-mediated progenitor proliferation. In contrast, no increase in [ 3 H]-thymidine incorporation is observed in retinal cultures treated only with IGF-1. Under serum starvation, while no increase in cell proliferation is detected in cultures treated only with ADP or IGF-1, a significant increase in [ 3 H]-thymidine incorporation and number of PCNA expressing cells is observed in cultures treated concomitantly with ADP plus IGF-1, suggesting that both molecules are required to induce proliferation of retinal progenitors. In serum-starved cultures, although an increase in cell viability is detected by MTT assays in IGF-1-treated cultures, no significant increase in viability of [ 3 H]-thymidine labeled progenitors is observed, suggesting that IGF-1 may contribute to survival of postmitotic cells in culture. While only ADP increases intracellular calcium, only IGF-1 induces the phosphorylation of Akt in the retinal cultures. IGF-1 through the PI3K/Akt pathway induces a significant increase in the transcription and expression of CDK1 with a decrease in phospho-histone H3 expression that is concomitant with an increase in the expression of cyclins D1 and E and CDK2. These findings suggest that IGF-1 stimulates CDK-1 mRNA and protein expression that enable progenitors to progress through the cell cycle. However, signaling of ADP in the presence IGF-I seems to be required for DNA synthesis. (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.) |
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معلومات مُعتمدة: | CAPES-AUXPE-PNPD2808/2010 Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior; CAPES-AUXPE-PNPD2808/2010 Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior; CAPES-AUXPE-PNPD2808/2010 Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior; FAPERJ- E26-111.327/2013 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; CNPq-303018/2016-0 Conselho Nacional de Desenvolvimento Científico e Tecnológico |
فهرسة مساهمة: | Keywords: Calcium; Cell proliferation; P2Y receptors; PI3K/Akt; Retina development |
تواريخ الأحداث: | Date Created: 20231227 Latest Revision: 20231227 |
رمز التحديث: | 20231228 |
DOI: | 10.1007/s11302-023-09982-7 |
PMID: | 38151691 |
قاعدة البيانات: | MEDLINE |
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