دورية أكاديمية
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Kv3.1 Voltage-gated Potassium Channels Modulate Anxiety-like Behaviors in Female Mice.

التفاصيل البيبلوغرافية
العنوان: Kv3.1 Voltage-gated Potassium Channels Modulate Anxiety-like Behaviors in Female Mice.
المؤلفون: Page CE; Department of Neuroscience, The Ohio State University, Columbus, OH, United States., Coutellier L; Department of Neuroscience, The Ohio State University, Columbus, OH, United States; Department of Psychology, The Ohio State University, Columbus, OH, United States. Electronic address: Coutellier.8@osu.edu.
المصدر: Neuroscience [Neuroscience] 2024 Feb 06; Vol. 538, pp. 68-79. Date of Electronic Publication: 2023 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Potassium Channels, Voltage-Gated*/metabolism, Male ; Mice ; Female ; Animals ; Neurons/metabolism ; Interneurons/metabolism ; Brain/metabolism ; Anxiety/metabolism ; Shaw Potassium Channels/metabolism
مستخلص: Inhibitory parvalbumin (PV) interneurons regulate the activity of neural circuits within brain regions involved in emotional processing, including the prefrontal cortex (PFC). Recently, rodent studies have implicated a stress-induced increase in prefrontal PV neuron activity in the development of anxiety behaviors, particularly in females. However, the mechanisms through which stress increases activity of prefrontal PV neurons remain unknown. The fast-spiking properties of PV neurons in part come from their expression of voltage-gated potassium (K+) ion channels, particularly Kv3.1 channels. We therefore suggest that stress-induced changes in Kv3.1 channels contribute to the appearance of an anxious phenotype following chronic stress in female mice. Here, we first showed that unpredictable chronic mild stress (UCMS) increased expression of Kv3.1 channels on prefrontal PV neurons in female mice, a potential mechanism underlying the previously observed hyperactivity of these neurons after stress. We then showed that female mice deficient in Kv3.1 channels displayed resilience to UCMS-induced anxiety-like behaviors. Altogether, our findings implicate Kv3.1 channels in the development of anxiety-like behaviors following UCMS, particularly in females, providing a novel mechanism to understand sex-specific vulnerabilities to stress-induced psychopathologies.
(Copyright © 2023 IBRO. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R21 MH119090 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: anxiety; chronic stress; parvalbumin neurons; potassium channels
المشرفين على المادة: 0 (Potassium Channels, Voltage-Gated)
0 (Shaw Potassium Channels)
تواريخ الأحداث: Date Created: 20231229 Date Completed: 20240205 Latest Revision: 20240218
رمز التحديث: 20240218
مُعرف محوري في PubMed: PMC10872248
DOI: 10.1016/j.neuroscience.2023.12.011
PMID: 38157976
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2023.12.011