Metastatic potentials classified with hypoxia-inducible factor 1 downstream genes in pan-cancer cell lines.

التفاصيل البيبلوغرافية
العنوان:	Metastatic potentials classified with hypoxia-inducible factor 1 downstream genes in pan-cancer cell lines.
المؤلفون:	Nakamichi K; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan., Yamamoto Y; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan., Semba K; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.; Translational Research Center, Fukushima Medical University, Fukushima, Japan., Nakayama J; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.; Department of Oncogenesis and growth Regulation, Research Institute, Osaka International Cancer Institute, Osaka, Japan.
المصدر:	Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2024 Feb; Vol. 29 (2), pp. 169-177. Date of Electronic Publication: 2023 Dec 29.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford, UK : Blackwell Science Ltd., 1996-
مواضيع طبية MeSH:	Hypoxia-Inducible Factor 1/genetics , Hypoxia-Inducible Factor 1/metabolism , Breast Neoplasms*/pathology, Humans ; Female ; Cell Line ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Cell Line, Tumor ; Cell Hypoxia/physiology
مستخلص:	Hypoxia-inducible factor 1 (HIF1) is a transcription factor that is stabilized under hypoxia conditions via post-translational modifications. HIF1 regulates tumor malignancy and metastasis by gene transcriptions, such as Warburg effect and angiogenesis-related genes, in cancer cells. However, the HIF1 downstream genes show varied expressional patterns in different cancer types. Herein, we performed the hierarchical clustering based on the HIF1 downstream gene expression patterns using 1406 cancer cell lines crossing 30 types of cancer to understand the relationship between HIF1 downstream genes and the metastatic potential of cancer cell lines. Two types of cancers, including bone and breast cancers, were classified based on HIF1 downstream genes with significantly altered metastatic potentials. Furthermore, different HIF1 downstream gene subsets were extracted to discriminate each subtype for these cancer types. HIF1 downstream subtyping classification will help to understand the novel insight into tumor malignancy and metastasis in each cancer type. (© 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.)
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معلومات مُعتمدة:	Fukushima Prefecture; JP21K15562 Japan Society for the Promotion of Science; JP23K06665 Japan Society for the Promotion of Science
فهرسة مساهمة:	Keywords: HIF1; cancer cell line; hierarchical clustering; metastatic potential
المشرفين على المادة:	0 (Hypoxia-Inducible Factor 1) 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
تواريخ الأحداث:	Date Created: 20231230 Date Completed: 20240206 Latest Revision: 20240206
رمز التحديث:	20240206
DOI:	10.1111/gtc.13092
PMID:	38158708
قاعدة البيانات:	MEDLINE

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تدمد:	1365-2443
DOI:	10.1111/gtc.13092