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Correlations between the Michigan Retinal Degeneration Questionnaire and visual function parameters in patients with retinitis pigmentosa.

التفاصيل البيبلوغرافية
العنوان: Correlations between the Michigan Retinal Degeneration Questionnaire and visual function parameters in patients with retinitis pigmentosa.
المؤلفون: Karuntu JS; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands., Nguyen XT; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands., Boon CJF; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Ophthalmology, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.
المصدر: Acta ophthalmologica [Acta Ophthalmol] 2024 Aug; Vol. 102 (5), pp. 555-563. Date of Electronic Publication: 2023 Dec 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101468102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-3768 (Electronic) Linking ISSN: 1755375X NLM ISO Abbreviation: Acta Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK ; Malden, MA : Blackwell Munksgaard
مواضيع طبية MeSH: Retinitis Pigmentosa*/physiopathology , Retinitis Pigmentosa*/diagnosis , Visual Acuity*/physiology , Quality of Life* , Visual Fields*/physiology, Humans ; Female ; Male ; Cross-Sectional Studies ; Middle Aged ; Prospective Studies ; Adult ; Surveys and Questionnaires ; Young Adult ; Visual Field Tests/methods ; Tomography, Optical Coherence/methods
مستخلص: Purpose: To validate the use of best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), low-luminance deficit (LLD; the difference between BCVA and LLVA), mean macular sensitivity and fixation stability as parameters of vision-related quality of life based on the novel Michigan Retinal Degeneration Questionnaire (MRDQ) in retinitis pigmentosa (RP) patients.
Methods: In this prospective cross sectional study, 30 patients with RP (47% female) were included with a median age of 41.0 years (interquartile range: 24.1-58.3 years). BCVA, LLVA and LLD were measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts. Mesopic microperimetry was performed to measure mean macular sensitivity and fixation stability. Patients completed a Dutch translation of the MRDQ which results in an experienced disability (Θ-)score of seven domains. Spearman's rank correlation was used.
Results: BCVA correlated significantly to the MRDQ domain of central vision (r = 0.657; p < 0.001) and colour vision (r = 0.524; p = 0.003). Lower LLVA significantly correlated to higher experienced disability in the MRDQ domains for central vision (=0.550; p = 0.002) and contrast sensitivity (r = 0.502; p = 0.005). LLD was significantly correlated to the MRDQ domains of scotopic function (r = -0.484; p = 0.007) and mesopic peripheral function (r = -0.533; p = 0.002). Lower mean macular sensitivity was significantly associated with high experienced disability in all domains except for photosensitivity.
Conclusions: The majority of the MRDQ domains is strongly associated with visual function parameters. These findings show that visual function measurements, especially LLVA, LLD and mean macular sensitivity on microperimetry, reflect vision-related quality of life and can be used as relevant outcome measures in clinical trials for RP.
(© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
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معلومات مُعتمدة: Stichting Retina Fonds; Stichting Steunfonds Uitzicht
فهرسة مساهمة: Keywords: Michigan Retinal Degeneration Questionnaire; low‐luminance visual acuity; microperimetry; retinitis pigmentosa
تواريخ الأحداث: Date Created: 20231230 Date Completed: 20240708 Latest Revision: 20240708
رمز التحديث: 20240708
DOI: 10.1111/aos.16601
PMID: 38158751
قاعدة البيانات: MEDLINE
الوصف
تدمد:1755-3768
DOI:10.1111/aos.16601