دورية أكاديمية
أعرض في EDS

Evaluation of an early-stage prototype polyurethane femoral head implant for hip arthroplasty.

التفاصيل البيبلوغرافية
العنوان: Evaluation of an early-stage prototype polyurethane femoral head implant for hip arthroplasty.
المؤلفون: Siroros N; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany.; Biomedical Engineering Institute, Chiang Mai University, Thailand.; Department of Mechanical Engineering, Faculty of Engineering, Chiang Mai University, Thailand., Merfort R; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany., Migliorini F; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany.; Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical University, 39100, Bolzano, Italy., Lecouturier S; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany., Leven S; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany., Praster M; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany., Hildebrand F; Department of Orthopaedics, Trauma and Reconstructive Surgery, University Medical Center RWTH Aachen, Germany., Eschweiler J; Department of Trauma and Reconstructive Surgery, BG Hospital Bergmannstrost, Halle (Saale), Germany.
المصدر: Journal of orthopaedics [J Orthop] 2023 Nov 29; Vol. 50, pp. 49-57. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: COAA Country of Publication: India NLM ID: 101233220 Publication Model: eCollection Cited Medium: Print ISSN: 0972-978X (Print) Linking ISSN: 0972978X NLM ISO Abbreviation: J Orthop Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Calicut, India] : COAA, [2004]-
مستخلص: Introduction: Thi study evalautes a new bone-preserving femoral head cover that mimics the articular cartilage of the femoral head.
Methods: A specially developed polyurethane (PU) was evaluated in biocompatibility (cytotoxicity test) and mechanical response to tensile loading. In the cytotoxicity test, steam sterilized (SS) and ethylene oxide sterilized (EtO) PU samples were incubated separately in a cell culture medium. The seeded cell line MG-63 was then added to these sample-incubated cell culture mediums. One negative control group and one positive control group were also evaluated. The cells in each group were cultured for seven days before being quantified using the alamarBlue assay. In the mechanical test, the femoral head cover implants were separated into three groups of three samples. Each group represented a different implant insertion idea: direct insertion ( uc sample) and another two insertion modes ( is and ss samples) representing implants with enclosure mechanisms. The test consisted of distance-controlled cyclic tensile loadings followed by a failure test.
Results: The cytotoxicity test results show no significant difference in fluorescence intensity between the negative control, the three SS groups, and one EtO group (P > 0.05). However, the other two EtO groups exhibit significantly lower fluorescence intensity compared with the negative control (P < 0.05). In the mechanical test, the is samples have the highest cyclic loading force at 559.50 ± 51.41 N, while the uc samples exhibit the highest force in the failure test at 632.16 ± 50.55 N. There are no significant differences (P > 0.05) among the uc, is, and ss groups in terms of stiffness.
Conclusion: The cytotoxicity test and the mechanical experiment provide initial assessments of the proposed PU femoral head cover implant. The evaluation outcomes of this study could serve as a foundation for developing more functional design and testing methods, utilizing numerical simulations, and developing animal/clinical trials in the future.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2023 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Bearings; Hip arthroplasty; Implant; Polyurethane
تواريخ الأحداث: Date Created: 20240101 Latest Revision: 20240125
رمز التحديث: 20240125
مُعرف محوري في PubMed: PMC10755531
DOI: 10.1016/j.jor.2023.11.067
PMID: 38162259
قاعدة البيانات: MEDLINE
الوصف
تدمد:0972-978X
DOI:10.1016/j.jor.2023.11.067