دورية أكاديمية
أعرض في EDS

Epidemiology of soil-transmitted helminth infections and the differential effect of treatment on the distribution of helminth species in rural areas of Gabon.

التفاصيل البيبلوغرافية
العنوان: Epidemiology of soil-transmitted helminth infections and the differential effect of treatment on the distribution of helminth species in rural areas of Gabon.
المؤلفون: Edoa JR; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon., Adégbitè BR; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam Public Health, Amsterdam Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Fondation Pour la Recherche Scientifique, ISBA, P.O. Box 88, Cotonou, Bénin., Honkpéhèdji YJ; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Fondation Pour la Recherche Scientifique, ISBA, P.O. Box 88, Cotonou, Bénin.; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Zinsou JF; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Fondation Pour la Recherche Scientifique, ISBA, P.O. Box 88, Cotonou, Bénin.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany., Boussougou-Sambe ST; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany., Woldearegai TG; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.; German Center for Infection Research, Tübingen, Germany., Mordmüller B; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands., Adegnika AA; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon.; Fondation Pour la Recherche Scientifique, ISBA, P.O. Box 88, Cotonou, Bénin.; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.; German Center for Infection Research, Tübingen, Germany., Dejon-Agobé JC; Centre de Recherches Médicales de Lambaréné, P.O. Box 242, Lambaréné, Gabon. jcagobe@gmail.com.
المصدر: Tropical medicine and health [Trop Med Health] 2024 Jan 02; Vol. 52 (1), pp. 3. Date of Electronic Publication: 2024 Jan 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: Japan NLM ID: 101215093 Publication Model: Electronic Cited Medium: Print ISSN: 1348-8945 (Print) Linking ISSN: 13488945 NLM ISO Abbreviation: Trop Med Health Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2016- > : London : BioMed Central Ltd.
Original Publication: Nagasaki, Japan : Japanese Society of Tropical Medicine, [2004]-
مستخلص: Background: Soil-transmitted helminth (STH) infections are a public health concern in endemic areas. For efficient control, the epidemiology of the disease needs to be monitored. This report assesses the prevalence, incidence, post-treatment infection (PTI) rate, and risk factors for STH infections in two rural areas of Gabon.
Method: In this longitudinal and prospective study, participants aged six to 30 years from the vicinity of Lambaréné and selected households using a simple randomization process were included and followed in two consecutive periods of six and nine months. Stool samples were obtained at the beginning and the end of each follow-up phase (FUP). The Kato-Katz technique was used for the detection of STH eggs, while the Harada-Mori technique and coproculture were used for the detection of larvae in stool processed within a maximum of four hours of collection. Prevalence was determined at the three main time points of the study, incidence was assessed during the two study phases, and PTI was defined as an infection detected nine months post-treatment.
Results: A total of 262 participants were included. The overall prevalence of STH infections was 42% (95%CI: 34-50) and 44% (95%CI: 37-51) at baseline for the six and nine month FUPs, respectively. Trichuris trichiura was the most prevalent species at each time point of assessment. The cumulative incidence of STH at the 6- and 9-month follow-ups was 18% (95%CI: 12-27) and 35% (95%CI: 27-43), respectively, while the incidence rates were 41 (95%CI: 28-55) and 56 (95%CI: 46-67) per 100 person-years, respectively. The PTI rates at the 9-month follow-up for T. trichiura, hookworm, and Ascaris lumbricoides were 58% (95%CI: 41-74), 31% (95%CI: 11-59) and 18% (95%CI: 5-40), respectively. The STH infection intensity was generally light.
Conclusion: The prevalence level of STH infection is moderate in the vicinity of Lambaréné, with T. trichiura being the most prevalent species. Our results reveal a rapid spread of the disease in the population mainly following intervention, particularly for trichuriasis, and therefore call for the full implementation of the World Health Organization's recommendations in the area. Trial registration clinicaltrials.gov Identifier NCT02769013. Registered 21 April 2016, https://clinicaltrials.gov/study/NCT02769013.
(© 2023. The Author(s).)
References: Trans R Soc Trop Med Hyg. 1987;81(6):987-93. (PMID: 3503421)
Trop Med Infect Dis. 2018 Nov 11;3(4):. (PMID: 30423901)
J Infect Dis. 2007 Dec 1;196(11):1671-8. (PMID: 18008252)
PLoS One. 2022 Aug 12;17(8):e0272821. (PMID: 35960935)
Infect Dis Poverty. 2022 Mar 10;11(1):28. (PMID: 35272701)
Ethiop J Health Sci. 2013 Nov;23(3):237-44. (PMID: 24307823)
Parasit Vectors. 2019 Dec 10;12(1):577. (PMID: 31823806)
Adv Parasitol. 2016;94:133-198. (PMID: 27756454)
J Biomed Inform. 2009 Apr;42(2):377-81. (PMID: 18929686)
Southeast Asian J Trop Med Public Health. 1992 Jun;23(2):219-27. (PMID: 1439973)
PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663. (PMID: 30080853)
Am J Trop Med Hyg. 2020 Jul;103(1):325-333. (PMID: 32431272)
BMC Infect Dis. 2009 Feb 19;9:20. (PMID: 19228385)
BMJ. 2017 Sep 25;358:j4307. (PMID: 28947636)
Sci Rep. 2022 Mar 17;12(1):4586. (PMID: 35302056)
PLoS Negl Trop Dis. 2012;6(5):e1621. (PMID: 22590656)
Infect Dis Poverty. 2018 Jan 30;7(1):6. (PMID: 29378644)
Trop Med Int Health. 2014 Jul;19(7):812-24. (PMID: 24750543)
Trop Med Infect Dis. 2020 Jun 05;5(2):. (PMID: 32516900)
Mem Inst Oswaldo Cruz. 2001 Oct;96(7):903-9. (PMID: 11685253)
Chest. 2020 Jul;158(1S):S12-S20. (PMID: 32658647)
Parasit Vectors. 2016 Mar 02;9:123. (PMID: 26935065)
PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2651. (PMID: 24722335)
PLoS Negl Trop Dis. 2018 Jun 4;12(6):e0006562. (PMID: 29864132)
J Parasitol Res. 2019 Feb 4;2019:6438497. (PMID: 30863624)
PLoS Negl Trop Dis. 2023 May 17;17(5):e0011345. (PMID: 37196007)
JAMA. 2008 Apr 23;299(16):1937-48. (PMID: 18430913)
Antimicrob Agents Chemother. 2014 May;58(5):2535-40. (PMID: 24550339)
J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):185-7. (PMID: 26312010)
معلومات مُعتمدة: MO 1071/12-1 Deutsche Forschungsge-meinschaft
فهرسة مساهمة: Keywords: Anthelminthic treatment; Ascaris lumbricoides; Epidemiology; Gabon; Hookworm; Incidence; Prevalence; Trichuris trichiura
سلسلة جزيئية: ClinicalTrials.gov NCT02769013
تواريخ الأحداث: Date Created: 20240102 Latest Revision: 20240104
رمز التحديث: 20240104
مُعرف محوري في PubMed: PMC10759385
DOI: 10.1186/s41182-023-00567-z
PMID: 38163912
قاعدة البيانات: MEDLINE
الوصف
تدمد:1348-8945
DOI:10.1186/s41182-023-00567-z