دورية أكاديمية
The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study.
| العنوان: | The impact of hospitalization on mortality in patients with connective tissue disease-associated interstitial lung disease: a medical records review study. |
|---|---|
| المؤلفون: | Korogodina A; Department of Medicine, Montefiore Medical Center-Wakefield/Albert Einstein College of Medicine, Bronx, NY, USA. korogodina.a@hotmail.com., Kaur N; Touro University Medical Group, Stockton, CA, USA., Xie X; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Mehta A; Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Cleven KL; Division of Pulmonary Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA., Ayesha B; Division of Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA., Kumthekar A; Division of Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA. |
| المصدر: | Advances in rheumatology (London, England) [Adv Rheumatol] 2024 Jan 02; Vol. 64 (1), pp. 1. Date of Electronic Publication: 2024 Jan 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101734172 Publication Model: Electronic Cited Medium: Internet ISSN: 2523-3106 (Electronic) Linking ISSN: 25233106 NLM ISO Abbreviation: Adv Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2018]- |
| مواضيع طبية MeSH: | Connective Tissue Diseases*/complications , Lung Diseases, Interstitial*/complications , Lung Diseases, Interstitial*/therapy , Scleroderma, Systemic*/complications, Female ; Humans ; Male ; Hospitalization ; Medical Records |
| مستخلص: | Background: Interstitial lung disease (ILD) remains one of the most important causes of morbidity and mortality in patients with Connective Tissue Diseases (CTD). This study evaluated the impact of hospitalization on mortality in an ethnically and racially diverse cohort of CTD-ILD patients. Methods: We conducted a medical records review study at Montefiore Medical Center, Bronx, NY. We included 96 patients and collected data on demographic characteristics, reasons for hospitalization, length of stay, immunosuppressant therapy use, and mortality. We stratified our patients into two cohorts: hospitalized and non-hospitalized. The hospitalized cohort was further subdivided into cardiopulmonary and non-cardiopulmonary admissions. Two-sample tests or Wilcoxon's rank sum tests for continuous variables and Chi-square or Fisher's exact tests for categorical variables were used for analyses as deemed appropriate. Results: We identified 213 patients with CTD-ILD. Out of them, 96 patients met the study's inclusion criteria. The majority of patients were females (79%), and self-identified as Hispanic (54%) and Black (40%). The most common CTDs were rheumatoid arthritis (RA) (29%), inflammatory myositis (22%), and systemic sclerosis (15%). The majority (76%) of patients required at least one hospitalization. In the non-hospitalized group, no deaths were observed, however we noted significant increase of mortality risk in hospitalized group (p = 0.02). We also observed that prolonged hospital stay (> 7 days) as well as older age and male sex were associated with increased mortality. Conclusions: Prolonged (> 7 days) hospital stay and hospitalization for cardiopulmonary causes, as well as older age and male sex were associated with an increased mortality risk in our cohort of CTD-ILD patients. (© 2023. The Author(s).) |
| References: | Fischer A, Antoniou KM, Brown KK et al. An official European Respiratory Society/American Thoracic Society research statement: interstitial Pneumonia with autoimmune features. In: Eur Respir J. 2015;46. Jeganathan N, Sathananthan M. Connective tissue disease-related interstitial lung Disease: prevalence, patterns, predictors, prognosis, and treatment. Lung. 2020;198(5). Marie I, Hatron PY, Dominique S, Cherin P, Mouthon L, Menard JF. Short-term and long-term outcomes of interstitial lung Disease in polymyositis and dermatomyositis: a series of 107 patients. Arthritis Rheum. 2011;63(11). Dubreuil M, Rho YH, Man A et al. Diabetes incidence in psoriatic arthritis, psoriasis and rheumatoid arthritis: a UK population-based cohort study. Rheumatol (United Kingdom). 2014;53(2). Chung L, Krishnan E, Chakravarty EF. Hospitalizations and mortality in systemic sclerosis: results from the Nationwide Inpatient Sample. Rheumatology. 2007;46(12). Raimundo K, Solomon JJ, Olson AL et al. Correction: rheumatoid arthritis-interstitial lung Disease in the United States: prevalence, incidence, and healthcare costs and mortality. J Rheumatol. 2019;46(2). Gunen H, Hacievliyagil SS, Kosar F et al. Factors affecting survival of hospitalized patients with COPD. Eur Respir J. 2005;26(2). Akita K, Kohno T, Kohsaka S et al. Prognostic impact of previous hospitalization in acute Heart Failure patients. Circ J. 2019;83(6). Matsukawa R, Masuda S, Matsuura H et al. Early follow-up at outpatient care after discharge improves long-term Heart Failure readmission rate and prognosis. ESC Heart Fail. 2021;8(4). Brown AW, Fischer CP, Shlobin OA, et al. Outcomes after hospitalization in Idiopathic Pulmonary Fibrosis: a cohort study. Chest. 2015;147(1):173–9. (PMID: 10.1378/chest.13-242425188694) Oldham JM, Lee CT, Wu Z et al. Lung function trajectory in Progressive fibrosing interstitial lung Disease. Eur Respir J Published online 2021. Ratwani AP, Ahmad KI, Barnett SD, Nathan SD, Brown AW. Connective tissue disease-associated interstitial lung Disease and outcomes after hospitalization: a cohort study. Respir Med. 2019;154:1–5. (PMID: 10.1016/j.rmed.2019.05.02031176795) US Census Bureau. Bronx County QuickFacts.; 2020. Hyldgaard C, Bendstrup E, Pedersen AB, Pedersen L, Ellingsen T. Interstitial lung Disease in connective tissue Diseases: survival patterns in a population-based cohort. J Clin Med. 2021;10(21). Sankar S, Habib M, Jaafar S, et al. Hospitalizations related to systemic sclerosis and the impact of interstitial lung Disease. Analysis of patients hospitalized at the University of Michigan, USA. Clin Exp Rheumatol. 2021;39(Suppl 131):43–51. (PMID: 10.55563/clinexprheumatol/9ivp9g337349688324531) Gavrilov LA, Gavrilova NS. Mortality measurement at Advanced ages: a study of the Social Security Administration Death Master file. N Am Actuar J. 2011;15(3):432–47. (PMID: 10.1080/10920277.2011.10597629223080643269912) NYC Bureau of Vital Statistics. Premature Heart Disease and Stroke deaths among adults in New York City. Epi Data Brief. Published online November 2017. Chen X, Guo J, Yu D, Jie B, Zhou Y. Predictors of Mortality in Progressive Fibrosing interstitial lung Diseases. Front Pharmacol. 2021;12. |
| فهرسة مساهمة: | Keywords: Connective tissue Diseases; Hospitalization; Interstitial lung Disease; Mortality |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240105 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1186/s42358-023-00343-x |
| PMID: | 38167388 |
| قاعدة البيانات: | MEDLINE |
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