دورية أكاديمية
BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination.
| العنوان: | BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination. |
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| المؤلفون: | van Meijgaarden KE; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Li W; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany., Moorlag SJCFM; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Koeken VACM; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands., Koenen HJPM; Department of Laboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Joosten LAB; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Vyakarnam A; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bangalore, India.; Department of Immunobiology, School of Immunology & Microbial Sciences, Faculty of Life Science & Medicine, King's College, London, UK., Ahmed A; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bangalore, India., Rakshit S; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bangalore, India., Adiga V; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bangalore, India., Ottenhoff THM; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Li Y; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Joosten SA; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. s.a.joosten@lumc.nl. |
| المصدر: | Nature communications [Nat Commun] 2024 Jan 02; Vol. 15 (1), pp. 114. Date of Electronic Publication: 2024 Jan 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Mycobacterium* , Tuberculosis*/microbiology, Adult ; Infant ; Child ; Humans ; Child, Preschool ; BCG Vaccine ; Vaccination/methods |
| مستخلص: | Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial growth control, here we first investigate the effects of BCG-vaccination in healthy Dutch adults. About a quarter of individuals already control BCG-growth prior to vaccination, whereas a quarter of the vaccinees acquires the capacity to control BCG upon vaccination. This leaves half of the population incapable to control BCG-growth. Single cell RNA sequencing identifies multiple processes associated with mycobacterial growth control. These data suggest (i) that already controllers employ different mechanisms to control BCG-growth than acquired controllers, and (ii) that half of the individuals fail to develop measurable growth control irrespective of BCG-vaccination. These results shed important new light on the variable immune responses to mycobacteria in humans and may impact on improved vaccination against tuberculosis and other diseases. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 643381 European Commission (EC); 833247 EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council); 948207 EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council); spinoza MN Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research); aspasia YL Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research); Hypatia YL Radboud Universitair Medisch Centrum (Radboudumc); WL CSC | Chinese Government Scholarship |
| المشرفين على المادة: | 0 (BCG Vaccine) |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240105 Latest Revision: 20240822 |
| رمز التحديث: | 20240823 |
| مُعرف محوري في PubMed: | PMC10761850 |
| DOI: | 10.1038/s41467-023-44252-5 |
| PMID: | 38167829 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-44252-5 |