دورية أكاديمية
أعرض في EDS

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.

التفاصيل البيبلوغرافية
العنوان: Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.
المؤلفون: Zhang KH; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China.; Pediatric Research Institute, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan 250022, China., Zhang FF; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Zhang ZL; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China.; School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China., Fang KF; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Sun WX; Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong 226019, China., Kong N; Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China., Wu M; Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China., Liu HO; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Liu Y; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Li Z; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Cai QQ; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Wang Y; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Wei QW; Department of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210014, China., Lin PC; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities, Xining 810007, China., Lin Y; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China., Xu W; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China.; Shanghai Fifth People's Hospital of Fudan University, Fudan University, Shanghai 200240, China., Xu CJ; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China., Yuan YY; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China., Zhao SM; The Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200090, China.; Shanghai Key Laboratory of Metabolic Remodeling, and Children's Hospital of Fudan University, Shanghai 200032, China.; School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China.; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities, Xining 810007, China.
المصدر: Protein & cell [Protein Cell] 2024 Jul 01; Vol. 15 (7), pp. 512-529.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Oxford] : Oxford University Press
Original Publication: Heidelberg : Beijing, China : Springer ; Higher Education Press
مواضيع طبية MeSH: Granulosa Cells*/metabolism , Granulosa Cells*/drug effects , Glutamine*/metabolism , Follicle Stimulating Hormone*/metabolism , Ovulation* , Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/pathology, Animals ; Female ; Mice ; Humans ; Apoptosis/drug effects ; MAP Kinase Kinase Kinase 5/metabolism ; MAP Kinase Kinase Kinase 5/genetics ; Swine ; Mice, Inbred C57BL
مستخلص: Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Inadequate understanding of the ovulation drivers hinders PCOS intervention. Herein, we report that follicle stimulating hormone (FSH) controls follicular fluid (FF) glutamine levels to determine ovulation. Murine ovulation starts from FF-exposing granulosa cell (GC) apoptosis. FF glutamine, which decreases in pre-ovulation porcine FF, elevates in PCOS patients FF. High-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal, metabolic, and morphologic PCOS traits. Mechanistically, follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine, which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic pathway. FSH and glutamine inhibit the rapture of cultured murine follicles. Glutamine removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or EsR1-KO. These suggest that glutamine, FSH, and ASK1-JNK pathway are targetable to alleviate PCOS.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.)
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معلومات مُعتمدة: 2018YFA0800300 State Key Development Programs of China; 92253305 National Natural Science Foundation of China; 21XD1423000 Program of Shanghai Academic Research Leader; 2022M721954 China postdoctoral science foundation
فهرسة مساهمة: Keywords: FSH; PCOS; glutamine; granulosa cells; ovulation
المشرفين على المادة: 0RH81L854J (Glutamine)
9002-68-0 (Follicle Stimulating Hormone)
EC 2.7.11.25 (MAP Kinase Kinase Kinase 5)
EC 2.7.11.25 (Map3k5 protein, mouse)
تواريخ الأحداث: Date Created: 20240103 Date Completed: 20240630 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC11214834
DOI: 10.1093/procel/pwad065
PMID: 38167949
قاعدة البيانات: MEDLINE
الوصف
تدمد:1674-8018
DOI:10.1093/procel/pwad065