دورية أكاديمية
The ability of a 3-gene host signature in blood to distinguish tuberculous meningitis from other brain infections.
| العنوان: | The ability of a 3-gene host signature in blood to distinguish tuberculous meningitis from other brain infections. |
|---|---|
| المؤلفون: | Huynh J; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX1 4BHUnited Kingdom., Le NHT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nguyen BHL; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hoang HT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Do TAD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Trinh TTB; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Vu DTM; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Do VD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Ngiem NM; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Donovan J; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX1 4BHUnited Kingdom., Nguyen PH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; School of Medicine, Vietnam National University of Ho Chi Minh City, Vietnam., Dang TV; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nguyen TTA; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nguyen BD; Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam., Dang HMT; Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam., Ho NTD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Le TV; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX1 4BHUnited Kingdom., Le VH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX1 4BHUnited Kingdom., Thuong NTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford OX1 4BHUnited Kingdom. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Jan 03. Date of Electronic Publication: 2024 Jan 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مستخلص: | Background: Tuberculous meningitis (TBM) is difficult to diagnose. We investigated whether a 3-gene host response signature in blood can distinguish TBM from other brain infections. Methods: The expression of 3 genes (Dual specificity phosphatase 3- DUSP3, Guanylate-binding protein- GBP5, Krupple-like factor 2- KLF2) was analysed by RNA sequencing of archived whole blood from four cohorts of Vietnamese adults: 281 with TBM; 279 with pulmonary tuberculosis; 50 with other brain infections; and 30 healthy controls. 'TB scores' (combined 3-gene expression) were calculated following published methodology and discriminatory performance compared using area under a receiver operator characteristic curve (AUC). Results: GBP5 was upregulated in TBM compared to other brain infections (p < 0.001), with no difference in DUSP3 and KLF2 expression. The diagnostic performance of GBP5 alone (AUC 0.74 (95% CI 0.67-0.81)) was slightly better than the 3-gene TB score (AUC 0.66, 95% CI 0.58-0.73) in TBM. Both GBP5 expression and TB score were higher in HIV-positive participants (P < 0.001), with good diagnostic performance of GBP5 alone (AUC 0.86, 95% CI 0.80-0.93). Conclusion: The 3-gene host signature in whole blood has the ability to discriminate TBM from other brain infections, including in HIV-positive individuals. Validation in large prospective diagnostic study is now required. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| فهرسة مساهمة: | Keywords: 3 gene host response; HIV co-infection; brain infections; diagnosis; tuberculous meningitis |
| تواريخ الأحداث: | Date Created: 20240103 Latest Revision: 20240103 |
| رمز التحديث: | 20240104 |
| DOI: | 10.1093/infdis/jiad606 |
| PMID: | 38169323 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!