دورية أكاديمية
A bacterial pigment provides cross-species protection from H 2 O 2 - and neutrophil-mediated killing.
| العنوان: | A bacterial pigment provides cross-species protection from H |
|---|---|
| المؤلفون: | Liu Y; Department of Microbiology, Ohio State University, Columbus, OH 43210.; Department of Microbial Infection and Immunity, Ohio State University College of Medicine, Columbus, OH 43210., McQuillen EA; Department of Health and Rehabilitation Sciences, Ohio State University College of Medicine, Columbus, OH 43210., Rana PSJB; Department of Microbiology, Ohio State University, Columbus, OH 43210.; Department of Microbial Infection and Immunity, Ohio State University College of Medicine, Columbus, OH 43210., Gloag ES; Department of Microbial Infection and Immunity, Ohio State University College of Medicine, Columbus, OH 43210.; Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24060., Parsek MR; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195., Wozniak DJ; Department of Microbiology, Ohio State University, Columbus, OH 43210.; Department of Microbial Infection and Immunity, Ohio State University College of Medicine, Columbus, OH 43210. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 09; Vol. 121 (2), pp. e2312334121. Date of Electronic Publication: 2024 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Coinfection* , Staphylococcal Infections*/microbiology, Humans ; Animals ; Mice ; Staphylococcus aureus/genetics ; Hydrogen Peroxide/pharmacology ; Neutrophils ; Pseudomonas aeruginosa/genetics ; Biological Factors ; Biofilms |
| مستخلص: | Bacterial infections are often polymicrobial. Pseudomonas aeruginosa and Staphylococcus aureus cause chronic co-infections, which are more problematic than mono-species infections. Understanding the mechanisms of their interactions is crucial for treating co-infections. Staphyloxanthin (STX), a yellow pigment synthesized by the S. aureus crt operon, promotes S. aureus resistance to oxidative stress and neutrophil-mediated killing. We found that STX production by S. aureus , either as surface-grown macrocolonies or planktonic cultures, was elevated when exposed to the P. aeruginosa exoproduct, 2-heptyl-4-hydroxyquinoline N-oxide (HQNO). This was observed with both mucoid and non-mucoid P. aeruginosa strains. The induction phenotype was found in a majority of P. aeruginosa and S. aureus clinical isolates examined. When subjected to hydrogen peroxide or human neutrophils, P. aeruginosa survival was significantly higher when mixed with wild-type (WT) S. aureus , compared to P. aeruginosa alone or with an S. aureus crt mutant deficient in STX production. In a murine wound model, co-infection with WT S. aureus , but not the STX-deficient mutant, enhanced P. aeruginosa burden and disease compared to mono-infection. In conclusion, we identified a role for P. aeruginosa HQNO mediating polymicrobial interactions with S. aureus by inducing STX production, which consequently promotes resistance to the innate immune effectors H Competing Interests: Competing interests statement:The authors declare no competing interest. |
| التعليقات: | Update of: bioRxiv. 2023 Jan 17:2023.01.15.524085. doi: 10.1101/2023.01.15.524085. (PMID: 36711503) |
| References: | Front Cell Infect Microbiol. 2014 Jul 28;4:99. (PMID: 25120957) Antimicrob Agents Chemother. 2011 Feb;55(2):526-31. (PMID: 21115796) Curr Biol. 2016 Jan 25;26(2):195-206. (PMID: 26776731) mBio. 2016 May 24;7(3):. (PMID: 27222468) BMC Microbiol. 2007 Nov 06;7:99. (PMID: 17986343) J Bacteriol. 2020 Mar 26;202(8):. (PMID: 31792010) J Bacteriol. 1994 Dec;176(24):7719-26. (PMID: 8002598) Front Microbiol. 2022 Apr 25;13:845231. (PMID: 35547141) PLoS One. 2011;6(11):e27317. (PMID: 22076151) J Bacteriol. 2008 Feb;190(4):1247-55. (PMID: 18083812) Methods Mol Biol. 2007;412:15-20. (PMID: 18453102) J Biol Chem. 2018 Jun 15;293(24):9345-9357. (PMID: 29669807) Cell Microbiol. 2012 Jan;14(1):95-106. (PMID: 21951860) J Antimicrob Chemother. 1992 Nov;30(5):615-23. (PMID: 1493979) Sci Rep. 2020 Jun 18;10(1):9879. (PMID: 32555250) J Bacteriol. 1981 Sep;147(3):900-13. (PMID: 7275936) J Biol Chem. 1993 Apr 5;268(10):7503-8. (PMID: 8463280) Front Cell Infect Microbiol. 2019 Feb 28;9:33. (PMID: 30873388) J Am Coll Surg. 2012 Sep;215(3):388-99. (PMID: 22704819) BMC Microbiol. 2005 May 23;5:30. (PMID: 15907219) Front Microbiol. 2018 Apr 03;9:598. (PMID: 29666612) Infect Immun. 2006 Aug;74(8):4950-3. (PMID: 16861688) J Bacteriol. 2022 May 17;204(5):e0007622. (PMID: 35446119) FEMS Microbiol Ecol. 2011 Aug;77(2):413-28. (PMID: 21539583) Biochem J. 1956 May;63(1):130-7. (PMID: 13315258) J Pathol. 2014 Aug;233(4):331-343. (PMID: 24771509) mSphere. 2020 Jul 22;5(4):. (PMID: 32699119) mSphere. 2021 Jun 30;6(3):e0035821. (PMID: 34160233) NPJ Biofilms Microbiomes. 2017 Oct 19;3:25. (PMID: 29062489) Expert Rev Anti Infect Ther. 2015 May;13(5):605-13. (PMID: 25746414) PLoS One. 2013;8(2):e56846. (PMID: 23451098) Curr Microbiol. 2012 Dec;65(6):726-32. (PMID: 22965624) Biochim Biophys Acta. 1977 Jan 6;459(1):119-27. (PMID: 831781) ISME J. 2017 Oct;11(10):2233-2243. (PMID: 28548661) J Am Soc Mass Spectrom. 2004 Jun;15(6):862-9. (PMID: 15144975) Front Cell Infect Microbiol. 2017 Aug 25;7:373. (PMID: 28890882) Eur J Clin Microbiol Infect Dis. 2016 Jun;35(6):947-53. (PMID: 26993289) mBio. 2013 Feb 12;4(1):e00537-12. (PMID: 23404398) Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1339-44. (PMID: 14739337) mBio. 2021 Mar 30;12(2):. (PMID: 33785630) Biochem Biophys Res Commun. 2002 Oct 4;297(4):1003-7. (PMID: 12359254) Nat Commun. 2016 Jun 15;7:11951. (PMID: 27301800) Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19890-5. (PMID: 17172450) Trends Microbiol. 2009 Sep;17(9):406-13. (PMID: 19726196) Microbiology (Reading). 2020 Nov;166(11):1088-1094. (PMID: 33095698) Antimicrob Agents Chemother. 2019 May 24;63(6):. (PMID: 30988141) mBio. 2017 Mar 21;8(2):. (PMID: 28325763) Infect Drug Resist. 2013 Nov 06;6:175-86. (PMID: 24232573) Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2212340119. (PMID: 36520668) Infect Immun. 2006 Feb;74(2):910-9. (PMID: 16428734) Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4110-5. (PMID: 25775563) Plasmid. 2000 Jan;43(1):59-72. (PMID: 10610820) BMC Microbiol. 2010 Jan 30;10:33. (PMID: 20113519) Biochemistry. 1993 Apr 27;32(16):4403-10. (PMID: 8386545) Pathog Dis. 2018 Feb 1;76(1):. (PMID: 29342260) Microbiol Rev. 1996 Sep;60(3):539-74. (PMID: 8840786) Colloids Surf B Biointerfaces. 2013 Mar 1;103:502-9. (PMID: 23261573) PLoS One. 2015 Jun 22;10(6):e0129670. (PMID: 26098551) PLoS One. 2014 Jan 23;9(1):e86705. (PMID: 24466207) Infect Immun. 2017 Aug 18;85(9):. (PMID: 28630071) J Bacteriol. 2005 Jan;187(2):554-66. (PMID: 15629927) J Bacteriol. 2015 Jul;197(14):2252-64. (PMID: 25917910) Front Cell Infect Microbiol. 2017 Jun 30;7:286. (PMID: 28713774) J Bacteriol. 2007 Nov;189(22):8079-87. (PMID: 17873029) J Exp Med. 2005 Jul 18;202(2):209-15. (PMID: 16009720) Ann Am Thorac Soc. 2014 Jan;11 Suppl 1:S61-5. (PMID: 24437409) |
| معلومات مُعتمدة: | R01 AI143916 United States AI NIAID NIH HHS; UL1 TR002733 United States TR NCATS NIH HHS; R01 AI077628 United States AI NIAID NIH HHS; P30 CA016058 United States CA NCI NIH HHS; R01 AI134895 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Pseudomonas aeruginosa; Staphylococcus aureus; Staphyloxanthin; innate immunity; polymicrobial |
| المشرفين على المادة: | BBX060AN9V (Hydrogen Peroxide) 0 (Biological Factors) |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240105 Latest Revision: 20240617 |
| رمز التحديث: | 20240617 |
| مُعرف محوري في PubMed: | PMC10786307 |
| DOI: | 10.1073/pnas.2312334121 |
| PMID: | 38170744 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.2312334121 |