| المؤلفون: |
Shirato K; Department of Virology III, National Institute of Infectious Diseases, Japan., Suwa R; Department of Virology III, National Institute of Infectious Diseases, Japan., Nao N; Department of Virology III, National Institute of Infectious Diseases, Japan.; One Health Research Center, International Institute for Zoonosis Control, Hokkaido University, Japan.; Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Japan., Kawase M; Department of Virology III, National Institute of Infectious Diseases, Japan., Sugimoto S; Department of Virology III, National Institute of Infectious Diseases, Japan.; Management Department of Biosafety, Laboratory Animals, and Pathogen Bank, National Institute of Infectious Diseases, Japan., Kume Y; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Chishiki M; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Ono T; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Okabe H; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Norito S; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Sato M; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Sakuma H; Hoshi General Hospital, Japan., Suzuki S; Ohara General Hospital, Japan., Hosoya M; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan., Takeda M; Department of Virology III, National Institute of Infectious Diseases, Japan.; Department of Microbiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan., Hashimoto K; Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan. |
| مستخلص: |
Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G protein) gene sequences. The A2 subgroup is further separated into three subdivisions, A2a, A2b (A2b1), and A2c (A2b2). Subgroup A2c viruses carrying 180- or 111-nucleotide duplications in the G gene (A2c 180nt-dup or A2c 111nt-dup ) have been reported in Japan and Spain. The coronavirus disease 2019 (COVID-19) pandemic disrupted the epidemiological kinetics of other respiratory viruses, including hMPV. In this study, we analyzed the sequences of hMPV isolates in Tokyo and Fukushima obtained from 2017 to 2022, i.e., before and after the COVID-19 pandemic. Subgroup A hMPV strains were detected from 2017 to 2019, and most cases were A2c 111nt-dup , suggesting ongoing transmission of this clade, consistent with global transmission dynamics. Subgroup B viruses, but not subgroup A viruses, were detected in 2022 after the COVID-19 peak. Phylogenetic analysis showed that the subgroup B viruses were closely related to strains detected in Yokohama from 2013 to 2016, and strains detected in Fukushima in 2019, suggesting the reappearance of local endemic viruses in East Japan. |
