دورية أكاديمية
Building pathology capacity in sub-Saharan Africa to improve breast cancer diagnosis and treatment: training laboratory technicians in high-quality manual immunohistochemistry.
| العنوان: | Building pathology capacity in sub-Saharan Africa to improve breast cancer diagnosis and treatment: training laboratory technicians in high-quality manual immunohistochemistry. |
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| المؤلفون: | Setiawan L; BIO Ventures for Global Health, Seattle, WA, USA., Graef K; BIO Ventures for Global Health, Seattle, WA, USA., Schmolze D; Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Alem A; Pathology Department, Hawassa University College of Health Science, Hawassa, Ethiopia., Taylor L; Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. ltaylor@coh.org. |
| المصدر: | BMC cancer [BMC Cancer] 2024 Jan 03; Vol. 24 (1), pp. 32. Date of Electronic Publication: 2024 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnosis , Breast Neoplasms*/therapy , Laboratory Personnel*, Humans ; Female ; Immunohistochemistry ; Africa South of the Sahara ; Educational Status |
| مستخلص: | Background: To address the need for a skilled workforce in breast cancer (BC) pathology in sub-Saharan Africa (SSA), we implemented an education program to train laboratory technicians in manual immunohistochemistry (IHC). Methods: A quality improvement education project was developed. Interactive webinars were held every six months with didactics and presentations from African experts with experience in IHC. We conducted knowledge assessments and surveys on current practice, equipment, and human resources. A digital mentorship platform (DMP) was created for discussions, sharing SOPs, and networking. For one year (2022-2023), we followed developments in pathology capacity, practice changes, and educational needs. A paired t-test was used to calculate the significance of changes in knowledge immediately after the webinar and comfort level with topics 35 days after the webinar. Results: Two hundred and sixty six participants from 10 SSA countries attended the first webinar, a series of six lectures on IHC theory, methods, and practice. Ninety-five participants from nine SSA countries provided a baseline assessment of pathology capacity and feedback. Mean knowledge increased by 17.4% immediately after the webinar (from 41.8% pre-webinar to 59.2% post, p = < 0.0001). Self-reported comfort level in topics 35 days after the webinar increased by 11.3%, but this was not statistically significant (mean 3.36 pre- to 3.74 post, p = 0.1). Over six months, recordings were accessed 412 times. After six months, the second webinar had 93 participants from eight SSA countries. Membership in the DMP increased from 64 to 172; recordings were viewed 412 times in six months; and 113 participants from nine SSA countries completed surveys. Among 74 respondents who perform IHC, 43.5% reported moderate or significant positive practice changes such as improved antigen retrieval techniques and optimization of preanalytical variables. Over half (52.7%, n = 39) reported the quality of slides had moderately or significantly improved. After one year, a third webinar had 98 participants from eight SSA countries. Thirty-eight completed surveys, DMP membership increased to 199, and 1 reported launching IHC in a lab in Nigeria. Conclusions: Our program 1) reached hundreds of participants and provided a baseline assessment of pathology capacity across nine SSA countries; 2) created a novel mechanism to build pathology capacity and assess progress with this cohort; and 3) improved practices and the preparation of slides for over half performing manual IHC. After one year, interest was sustained. Tracking impact on diagnosis and treatment of BC in the region is needed long-term. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Breast cancer; Education intervention; Immunohistochemistry; Pathology; Sub-Saharan Africa |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240105 Latest Revision: 20240106 |
| رمز التحديث: | 20240106 |
| مُعرف محوري في PubMed: | PMC10763384 |
| DOI: | 10.1186/s12885-023-11756-8 |
| PMID: | 38172837 |
| قاعدة البيانات: | MEDLINE |
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