دورية أكاديمية
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development.
| العنوان: | IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. |
|---|---|
| المؤلفون: | Goh W; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Sudholz H; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Foroutan M; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; oNKo-Innate Pty Ltd, Melbourne, Victoria, Australia., Scheer S; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg., Pfefferle A; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; oNKo-Innate Pty Ltd, Melbourne, Victoria, Australia., Delconte RB; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Meng X; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Shen Z; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Hennessey R; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Kong IY; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Schuster IS; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Andoniou CE; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Davis MJ; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.; Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.; The South Australian immunoGENomics Cancer Institute (SAiGENCI), Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia., Hediyeh-Zadeh S; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Souza-Fonseca-Guimaraes F; Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia., Parish IA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Beavis P; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Thiele D; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Chopin M; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Degli-Esposti MA; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Centre for Experimental Immunology, Lions Eye Institute, Nedlands, Western Australia, Australia., Cursons J; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; oNKo-Innate Pty Ltd, Melbourne, Victoria, Australia., Kallies A; Department of Microbiology & Immunology, Faculty of Medicine, Dentistry and Health Sciences & Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Rautela J; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; oNKo-Innate Pty Ltd, Melbourne, Victoria, Australia., Nutt SL; The Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Huntington ND; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. nicholas.huntington@monash.edu.; oNKo-Innate Pty Ltd, Melbourne, Victoria, Australia. nicholas.huntington@monash.edu. |
| المصدر: | Nature immunology [Nat Immunol] 2024 Feb; Vol. 25 (2), pp. 240-255. Date of Electronic Publication: 2024 Jan 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
| مواضيع طبية MeSH: | Transcription Factor AP-1*/genetics , Killer Cells, Natural*/metabolism, Receptors, Interleukin-15 ; Ikaros Transcription Factor/genetics ; Ikaros Transcription Factor/metabolism |
| مستخلص: | Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in innate lymphopoiesis is unknown. Using conditional genetic inactivation, we show that Ikzf1/Ikaros is essential for normal natural killer (NK) cell lymphopoiesis and IKZF1 directly represses Cish, a negative regulator of interleukin-15 receptor resulting in impaired interleukin-15 receptor signaling. Both Bcl2l11 and BIM levels, and intrinsic apoptosis were increased in Ikzf1-null NK cells, which in part accounts for NK lymphopenia as both were restored to normal levels when Ikzf1 and Bcl2l11 were co-deleted. Ikzf1-null NK cells presented extensive transcriptional alterations with reduced AP-1 transcriptional complex expression and increased expression of Ikzf2/Helios and Ikzf3/Aiolos. IKZF1 and IKZF3 directly bound AP-1 family members and deletion of both Ikzf1 and Ikzf3 in NK cells resulted in further reductions in Jun/Fos expression and complete loss of peripheral NK cells. Collectively, we show that Ikaros family members are important regulators of apoptosis, cytokine responsiveness and AP-1 transcriptional activity. (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
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| معلومات مُعتمدة: | 1195296 Department of Health | National Health and Medical Research Council (NHMRC); 1124784 Department of Health | National Health and Medical Research Council (NHMRC) |
| المشرفين على المادة: | 0 (Transcription Factor AP-1) 0 (Receptors, Interleukin-15) 148971-36-2 (Ikaros Transcription Factor) |
| تواريخ الأحداث: | Date Created: 20240105 Date Completed: 20240205 Latest Revision: 20240206 |
| رمز التحديث: | 20240206 |
| DOI: | 10.1038/s41590-023-01718-4 |
| PMID: | 38182668 |
| قاعدة البيانات: | MEDLINE |
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