دورية أكاديمية
Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities.
| العنوان: | Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities. |
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| المؤلفون: | Barasch E; De Matteis Cardiovascular Institute, St. Francis Hospital, The Heart Center/SUNY at Stony Brook, 11537 Roslyn, NY, USA., Gottdiener J; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Buzkova P; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Cappola A; Division of Endocrinology, University of Pennsylvania, Philadelphia, PA 19104, USA., Shah S; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., DeFilippi C; Division of Cardiology, Inova Health System, Falls Church, VA 22031, USA., Gardin J; Department of Medicine, Division of Cardiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA., Kizer JR; Cardiology Section, San Francisco Veterans Affairs Health Care System, and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94121, USA. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Sep 16; Vol. 109 (10), pp. e1847-e1856. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Hyperthyroidism*/complications , Hyperthyroidism*/epidemiology , Hypothyroidism*/complications , Hypothyroidism*/epidemiology , Hypothyroidism*/physiopathology , Biomarkers*/blood, Humans ; Male ; Female ; Aged ; Cross-Sectional Studies ; Aged, 80 and over ; Echocardiography ; Peptide Fragments/blood ; Natriuretic Peptide, Brain/blood ; Heart Diseases/epidemiology ; Heart Diseases/etiology ; Cohort Studies |
| مستخلص: | Context: The relationship between thyroid dysfunction and measures of myocardial disease in older individuals remains to be defined. Objective: To evaluate the impact of thyroid dysfunction on structure and function of the left heart chambers and blood markers of cardiac disease. Methods: Cross-sectional analysis of the Cardiovascular Health Study, a community-based cohort of older individuals recruited from 4 urban areas in the United States. Of 3163 participants studied, 2477 were euthyroid, 465 had subclinical hypothyroidism (SCH), 47 overt hypothyroidism (OH), 45 endogenous (endo) subclinical hyperthyroidism (endo-SCT), and 129 had exogenous (exo) SCT due to thyroid hormone supplementation. Participants underwent clinical evaluation, blood sampling and biomarker measurement, 2-dimensional and speckle tracking echocardiography for assessment of left heart myocardial deformation, circulating biomarkers of diastolic overload (NT-proBNP), fibrosis (sST2, gal-3), and cardiomyocyte injury (hs-cTnT). Results: SCH was associated with higher NT-proBNP (beta = 0.17, P = .004), whereas OH was associated with higher hs-cTnT (beta = 0.29, P = .005). There were also suggestive associations of SCH with higher sST2, as well as endo-SCT with higher gal-3 and lower (worse) left atrial reservoir strain. Left ventricular longitudinal strain and end diastolic strain rate did not differ significantly from euthyroid participants in SCH, OH, or exo-SCT. Conclusion: In this free-living elderly cohort, subclinical and overt hypothyroidism were associated with abnormalities of blood biomarkers consistent with diastolic overload and myocardial necrosis respectively, whereas subclinical hyperthyroidism tended to be associated with myocardial fibrosis and decreased left atrial strain. Our findings could represent stage B heart failure and illuminate distinct aspects of the pathobiology of heart disease related to thyroid gland dysfunction with potential clinical implications. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
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| معلومات مُعتمدة: | United States HL NHLBI NIH HHS; K24 AG042765 United States AG NIA NIH HHS; United States NS NINDS NIH HHS; R01AG023629 United States AG NIA NIH HHS; United States NH NIH HHS; R01 AG023629 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: biomarkers; cardiac mechanics; subclinical hyperthyroidism; subclinical hypothyroidism |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Peptide Fragments) 114471-18-0 (Natriuretic Peptide, Brain) 0 (pro-brain natriuretic peptide (1-76)) |
| تواريخ الأحداث: | Date Created: 20240106 Date Completed: 20240916 Latest Revision: 20240918 |
| رمز التحديث: | 20240918 |
| مُعرف محوري في PubMed: | PMC11403323 |
| DOI: | 10.1210/clinem/dgae001 |
| PMID: | 38183678 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgae001 |