دورية أكاديمية
Effects of blackcurrant extract on indole and ammonia productions in an in vitro human fecal culture model.
| العنوان: | Effects of blackcurrant extract on indole and ammonia productions in an in vitro human fecal culture model. |
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| المؤلفون: | Ishiguro N; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan., Hayashi T; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan., Okayama M; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan., Yamaguchi T; Morishita Jintan Co., Ltd., 2-40, Tamatsukuri 1-Chome, Chuo-Ku, Osaka 540-8566, Japan., Kohno M; Morishita Jintan Co., Ltd., 2-40, Tamatsukuri 1-Chome, Chuo-Ku, Osaka 540-8566, Japan., Kawakami H; Morishita Jintan Co., Ltd., 2-40, Tamatsukuri 1-Chome, Chuo-Ku, Osaka 540-8566, Japan., Mitsunaga T; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan., Nakamura K; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan., Inagaki M; Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan. |
| المصدر: | Bioscience of microbiota, food and health [Biosci Microbiota Food Health] 2024; Vol. 43 (1), pp. 23-28. Date of Electronic Publication: 2023 Sep 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMFH Press Country of Publication: Japan NLM ID: 101578264 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2186-6953 (Print) Linking ISSN: 21863342 NLM ISO Abbreviation: Biosci Microbiota Food Health Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : BMFH Press |
| مستخلص: | Blackcurrant is available as a traditional medicine in Europe. However, the detailed effects of blackcurrant on the human gut microbiota remain unknown. In this study, we investigated the prebiotic effects of a blackcurrant extract using a human fecal culture model in six healthy subjects. Feces were individually inoculated into a medium with or without the blackcurrant extract and then fermented for 48 hr under anaerobic conditions. The results obtained from analysis of samples from the fermented medium demonstrated that after 48 hr of fermentation, the pH of the medium with the blackcurrant extract was significantly decreased (control, 6.62 ± 0.20; blackcurrant extract, 6.41 ± 0.33; p=0.0312). A 16S rRNA gene sequencing analysis of the microbiota of the fermented medium showed a significant increase in the relative abundance of Bifidobacteriacea e. In measuring the concentrations of putrefactive components in the fermented medium, we found that the blackcurrant extract significantly reduced ammonia levels and displayed a tendency toward reduced indole levels. Our results suggest that blackcurrant extract could be a potential ingredient for relief of putrefactive components in the gut. Competing Interests: There is no conflict of interest to declare. (©2024 BMFH Press.) |
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| فهرسة مساهمة: | Keywords: ammonia; blackcurrant extract; fecal fermentation; indole |
| تواريخ الأحداث: | Date Created: 20240108 Latest Revision: 20240109 |
| رمز التحديث: | 20240109 |
| مُعرف محوري في PubMed: | PMC10767324 |
| DOI: | 10.12938/bmfh.2022-094 |
| PMID: | 38188663 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2186-6953 |
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| DOI: | 10.12938/bmfh.2022-094 |