دورية أكاديمية
Thyroid status in pregnancy: Comparison of thyroid function abnormalities in women with and without a history of miscarriage or stillbirth.
| العنوان: | Thyroid status in pregnancy: Comparison of thyroid function abnormalities in women with and without a history of miscarriage or stillbirth. |
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| المؤلفون: | Abbas G; Ghulam Abbas, FCPS Department of Medicine, Khyber Teaching Hospital Peshawar, Pakistan., Sabir SA; Samina Aliya Sabir, FCPS Department of Obstetrics & Gynecology Lady Reading Hospital, Peshawar, Pakistan., Rehman SU; Siddiq Ur Rehman, MBBS, MRCP Royal Liverpool University Hospital, UK., Gohar B; Beenish Gohar, MBBS, Department of Obstetrics & Gynecology Hayatabad Medical Complex, Peshawar, Pakistan. |
| المصدر: | Pakistan journal of medical sciences [Pak J Med Sci] 2024 Jan-Feb; Vol. 40 (1Part-I), pp. 179-184. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Professional Medical Publications Country of Publication: Pakistan NLM ID: 100913117 Publication Model: Print Cited Medium: Print ISSN: 1682-024X (Print) Linking ISSN: 1681715X NLM ISO Abbreviation: Pak J Med Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi, Pakistan : Professional Medical Publications, [2000- |
| مستخلص: | Objective: To evaluate thyroid function tests (TFTs) during pregnancy in women with previous history of miscarriage or stillbirth. Methods: A cross-sectional study was carried out at the department of Obstetrics & Gynaecology and Endocrinology, Lady Reading Hospital, Peshawar from February 2021 to March 2022. All multigravida women attending the antenatal clinics were included using consecutive sampling. These women were placed into two groups, Group-A comprised of women with no prior history of miscarriages or stillbirths, and those with a history of foetal death during previous pregnancies were assigned Group-B. Free T4, thyroid stimulating hormone (TSH) and anti-thyroid peroxidase (TPO) antibodies were measured and the former two were used to label patients with thyroid dysfunction. Results: A total of 139 multigravida women were included in the study. About 43% of the women had a history of miscarriages or stillbirths. Thyroid dysfunction was observed overall in 36.69 % women, of whom 25.18% had sub-clinical hypothyroidism, 6.47% had hypothyroidism and 5.04 % were sub-clinical hyperthyroid. Women in Group-B had more thyroid functions abnormalities compared to Group-A (p<0.05). Moreover, there was significant difference in median TSH and freeT4 between the groups (p<0.001). Overall, thyroid dysfunction was found in 66.67% of patients who had a history of foetal death. Conclusions: In pregnant women with a history of miscarriage or abortion, thyroid functions abnormalities are common therefore routine thyroid testing is advised in pregnant women to prevent adverse perinatal outcomes. (Copyright: © Pakistan Journal of Medical Sciences.) |
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| فهرسة مساهمة: | Keywords: Hyperthyroidism; Hypothyroidism; Miscarriage; Pregnancy; Stillbirth; Sub clinical hypothyroidism |
| تواريخ الأحداث: | Date Created: 20240110 Latest Revision: 20240111 |
| رمز التحديث: | 20240111 |
| مُعرف محوري في PubMed: | PMC10772434 |
| DOI: | 10.12669/pjms.40.1.7282 |
| PMID: | 38196450 |
| قاعدة البيانات: | MEDLINE |
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