دورية أكاديمية
أعرض في EDS

Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials.

التفاصيل البيبلوغرافية
العنوان: Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials.
المؤلفون: Cheung C; King's College London, London, United Kingdom., Boocock E; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, United Kingdom., Grande AJ; Department of Medicine, Universidade Estadual de Mato Grosso do Sul, Campo Grande, Brazil., Maddocks M; Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, United Kingdom.
المصدر: Asia-Pacific journal of oncology nursing [Asia Pac J Oncol Nurs] 2023 Nov 10; Vol. 10 (Suppl 1), pp. 100335. Date of Electronic Publication: 2023 Nov 10 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101673157 Publication Model: eCollection Cited Medium: Print ISSN: 2347-5625 (Print) Linking ISSN: 23475625 NLM ISO Abbreviation: Asia Pac J Oncol Nurs Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [2021]- : [New York] : Elsevier
Original Publication: Mumbai : Wolters Kluwer/Medknow Publications, [2014]-
مستخلص: Objective: Cachexia is a multifactorial syndrome characterised by involuntary weight loss and functional limitation. There is a strong theoretical rationale for the use of exercise in the management of cachexia, and evidence of benefit from exercise in general cancer patients. However, clinical studies of exercise interventions in cancer cachexia are limited. We aimed to synthesise current evidence on the delivery, acceptability, safety and outcomes of exercise interventions for adults with cancer cachexia.
Methods: We conducted a systematic review. Four databases were searched up to February 2023 for randomised (RCTs) and non-randomised (NRCTs) controlled studies. Eligibility and quality were independently assessed by two authors. Data on intervention components and structure, participant flow and adherence were tabulated. Clinical outcome data on body stature and composition, muscle strength, functional performance, and health-related quality of life were synthesised using effect direction plots.
Results: Twelve studies (9 RCTs, 3 NRCTs) involving a total of 898 patients (study range 20-374) as part of a multicomponent approach. Median programme completion was 75% (range 43%-100%) and adherence was generally high. Five adverse events were considered possibly related to an intervention, including muscle or joint pain, breathlessness on exertion. Overall, 12/16 (75%) outcomes demonstrated a positive direction of effect on body stature and composition, 8/10 (80%) on muscle strength, 14/22 (64%) on functional performance, and 3/8 (38%) on health-related quality of life. Multicomponent interventions showed more consistent effects on body stature, and resistance training interventions on muscle strength.
Conclusions: Exercise interventions appear to be safe and acceptable to people with cancer cachexia. Positive effects from exercise are more consistently observed for body stature or composition and muscle strength outcomes, than in functional capacity and health-related quality of life. The synergistic effects of exercise with other cachexia interventions, including drugs, should be examined in future robust studies.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: Cachexia; Cancer; Exercise; Function; Physical activity
تواريخ الأحداث: Date Created: 20240110 Latest Revision: 20240111
رمز التحديث: 20240111
مُعرف محوري في PubMed: PMC10772198
DOI: 10.1016/j.apjon.2023.100335
PMID: 38197041
قاعدة البيانات: MEDLINE
الوصف
تدمد:2347-5625
DOI:10.1016/j.apjon.2023.100335