دورية أكاديمية
Metacyclogenesis as the Starting Point of Chagas Disease.
| العنوان: | Metacyclogenesis as the Starting Point of Chagas Disease. |
|---|---|
| المؤلفون: | Ferreira AZL; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., de Araújo CN; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil.; Faculty of Ceilândia, University of Brasilia, Brasilia 70910-900, Brazil., Cardoso ICC; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., de Souza Mangabeira KS; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., Rocha AP; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., Charneau S; Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., Santana JM; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil., Motta FN; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil.; Faculty of Ceilândia, University of Brasilia, Brasilia 70910-900, Brazil., Bastos IMD; Pathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia, Brasilia 70910-900, Brazil. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Dec 21; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 21. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Chagas Disease* , Trypanosoma cruzi*, Humans |
| مستخلص: | Chagas disease is a neglected infectious disease caused by the protozoan Trypanosoma cruzi , primarily transmitted by triatomine vectors, and it threatens approximately seventy-five million people worldwide. This parasite undergoes a complex life cycle, transitioning between hosts and shifting from extracellular to intracellular stages. To ensure its survival in these diverse environments, T. cruzi undergoes extreme morphological and molecular changes. The metacyclic trypomastigote (MT) form, which arises from the metacyclogenesis (MTG) process in the triatomine hindgut, serves as a crucial link between the insect and human hosts and can be considered the starting point of Chagas disease. This review provides an overview of the current knowledge regarding the parasite's life cycle, molecular pathways, and mechanisms involved in metabolic and morphological adaptations during MTG, enabling the MT to evade the immune system and successfully infect human cells. |
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| معلومات مُعتمدة: | grant 88881.711954/2022-01 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; INCT-MCTI/CNPq/CAPES/FAPs 16/2014 National Council for Scientific and Technological Development; 00193-00000833/2021-57 Foundation for Research Support of the Federal District; 00193-00000229/2021-21 Foundation for Research Support of the Federal District; 00193-00000825/2021-19 Foundation for Research Support of the Federal District |
| فهرسة مساهمة: | Keywords: Chagas disease; Trypanosoma cruzi; metacyclic trypomastigote; metacyclogenesis; protozoan parasite |
| تواريخ الأحداث: | Date Created: 20240111 Date Completed: 20240112 Latest Revision: 20240113 |
| رمز التحديث: | 20240113 |
| مُعرف محوري في PubMed: | PMC10778605 |
| DOI: | 10.3390/ijms25010117 |
| PMID: | 38203289 |
| قاعدة البيانات: | MEDLINE |
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