Exercise microdosing for skeletal muscle health applications to spaceflight.

التفاصيل البيبلوغرافية
العنوان:	Exercise microdosing for skeletal muscle health applications to spaceflight.
المؤلفون:	Voss AC; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Chambers TL; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Gries KJ; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Jemiolo B; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Raue U; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Minchev K; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Begue G; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Lee GA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Trappe TA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Trappe SW; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States.
المصدر:	Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2024 May 01; Vol. 136 (5), pp. 1040-1052. Date of Electronic Publication: 2024 Jan 11.
نوع المنشور:	Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Bethesda, MD : American Physiological Society, c1985-
مواضيع طبية MeSH:	Space Flight/methods , Muscle, Skeletal/metabolism , Muscle, Skeletal/physiology , Exercise/physiology, Humans ; Male ; Adult ; Myosin Heavy Chains/metabolism ; Lactic Acid/blood ; Lactic Acid/metabolism ; RNA, Messenger/metabolism ; Catecholamines/metabolism ; Catecholamines/blood ; Exercise Test/methods ; Oxygen Consumption/physiology ; Muscle Proteins/metabolism
مستخلص:	Findings from a recent 70-day bedrest investigation suggested intermittent exercise testing in the control group may have served as a partial countermeasure for skeletal muscle size, function, and fiber-type shifts. The purpose of the current study was to investigate the metabolic and skeletal muscle molecular responses to the testing protocols. Eight males (29 ± 2 yr) completed muscle power (6 × 4 s; peak muscle power: 1,369 ± 86 W) and V̇o 2max (13 ± 1 min; 3.2 ± 0.2 L/min) tests on specially designed supine cycle ergometers during two separate trials. Blood catecholamines and lactate were measured pre-, immediately post-, and 4-h postexercise. Muscle homogenate and muscle fiber-type-specific [myosin heavy chain (MHC) I and MHC IIa] mRNA levels of exercise markers ( myostatin, IκBα, myogenin, MuRF-1, ABRA, RRAD, Fn14, PDK4 ) and MHC I , IIa , and IIx were measured from vastus lateralis muscle biopsies obtained pre- and 4-h postexercise. The muscle power test altered ( P ≤ 0.05) norepinephrine (+124%), epinephrine (+145%), lactate (+300%), and muscle homogenate mRNA ( IκBα, myogenin, MuRF-1, RRAD, Fn14 ). The V̇o 2max test altered ( P ≤ 0.05) norepinephrine (+1,394%), epinephrine (+1,412%), lactate (+736%), and muscle homogenate mRNA ( myostatin, IκBα, myogenin, MuRF-1, ABRA, RRAD, Fn14, PDK4 ). In general, both tests influenced MHC IIa muscle fibers more than MHC I with respect to the number of genes that responded and the magnitude of response. Both tests also influenced MHC mRNA expression in a muscle fiber-type-specific manner. These findings provide unique insights into the adaptive response of skeletal muscle to small doses of exercise and could help shape exercise dosing for astronauts and Earth-based individuals. NEW & NOTEWORTHY Declines in skeletal muscle health are a concern for astronauts on long-duration spaceflights. The current findings add to the growing body of exercise countermeasures data, suggesting that small doses of specific exercise can be beneficial for certain aspects of skeletal muscle health. This information can be used in conjunction with other components of existing exercise programs for astronauts and might translate to other areas focused on skeletal muscle health (e.g., sports medicine, rehabilitation, aging).
معلومات مُعتمدة:	NNX11AJ62G National Aeronautics and Space Administration (NASA)
فهرسة مساهمة:	Keywords: countermeasures; exercise; microgravity; muscle; weightlessness
المشرفين على المادة:	EC 3.6.4.1 (Myosin Heavy Chains) 33X04XA5AT (Lactic Acid) 0 (RNA, Messenger) 0 (Catecholamines) 0 (Muscle Proteins)
تواريخ الأحداث:	Date Created: 20240111 Date Completed: 20240423 Latest Revision: 20240423
رمز التحديث:	20240423
DOI:	10.1152/japplphysiol.00491.2023
PMID:	38205550
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1522-1601
DOI:	10.1152/japplphysiol.00491.2023