دورية أكاديمية
أعرض في EDS

Gut mycobiome dysbiosis after sepsis and trauma.

التفاصيل البيبلوغرافية
العنوان: Gut mycobiome dysbiosis after sepsis and trauma.
المؤلفون: Park G; Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA., Munley JA; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Kelly LS; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Kannan KB; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Mankowski RT; Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Sharma A; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Upchurch G; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Casadesus G; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Chakrabarty P; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Wallet SM; Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, 32611, USA., Maile R; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Bible LE; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Wang B; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, 32901, USA., Moldawer LL; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Mohr AM; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Efron PA; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL, 32611, USA., Nagpal R; Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA. rnagpal@fsu.edu.
المصدر: Critical care (London, England) [Crit Care] 2024 Jan 11; Vol. 28 (1), pp. 18. Date of Electronic Publication: 2024 Jan 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
أسماء مطبوعة: Publication: London, UK : BioMed Central Ltd
Original Publication: London : Current Science Ltd, c1997-
مواضيع طبية MeSH: Mycobiome* , Gastrointestinal Microbiome* , Sepsis*/complications, Humans ; Dysbiosis/complications ; Dysbiosis/microbiology ; Candida ; Bacteria ; Fungi
مستخلص: Background: Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts and perturbations in the fungal (mycobiome) community after severe infection or injury, particularly in patients experiencing chronic critical illness (CCI), remain unstudied.
Methods: We assess persistence of the gut mycobiome perturbation (dysbiosis) in patients experiencing CCI following sepsis or trauma for up to two-to-three weeks after intensive care unit hospitalization.
Results: We show that the dysbiotic mycobiome arrays shift toward a pathobiome state, which is more susceptible to infection, in CCI patients compared to age-matched healthy subjects. The fungal community in CCI patients is largely dominated by Candida spp; while, the commensal fungal species are depleted. Additionally, these myco-pathobiome arrays correlate with alterations in micro-ecological niche involving specific gut bacteria and gut-blood metabolites.
Conclusions: The findings reveal the persistence of mycobiome dysbiosis in both sepsis and trauma settings, even up to two weeks post-sepsis and trauma, highlighting the need to assess and address the increased risk of fungal infections in CCI patients.
(© 2024. The Author(s).)
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معلومات مُعتمدة: RM1 GM139690 United States GM NIGMS NIH HHS; T32 GM-008721 United States NH NIH HHS; RM1 GM139690 United States NH NIH HHS
فهرسة مساهمة: Keywords: Critical care; Critical illness; Dysbiosis; Fungi; Metabolome; Microbiota; Mycobiome; Pathobiome; Sepsis; Trauma
تواريخ الأحداث: Date Created: 20240111 Date Completed: 20240115 Latest Revision: 20240404
رمز التحديث: 20240405
مُعرف محوري في PubMed: PMC10785534
DOI: 10.1186/s13054-023-04780-4
PMID: 38212826
قاعدة البيانات: MEDLINE
الوصف
تدمد:1466-609X
DOI:10.1186/s13054-023-04780-4