دورية أكاديمية
Impact of apitherapy on canine, equine, and chicken lymphocytes, in vitro.
| العنوان: | Impact of apitherapy on canine, equine, and chicken lymphocytes, in vitro. |
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| المؤلفون: | Turn JT; Department of Small Animal Medicine & Surgery, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA; Department of Biomedical Sciences, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Mayer J; Department of Small Animal Medicine & Surgery, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Nagata K; Department of Small Animal Medicine & Surgery, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Banovic F; Department of Small Animal Medicine & Surgery, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Meichner K; Department of Pathology, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Hurley DJ; Department of Population Health, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA., Koslowski E; ETR Laboratories, Inc., Leominster, MA, USA., Gogal RM Jr; Department of Biomedical Sciences, University of Georgia, Athens, Georgia, and ETR Laboratories, Inc., Leominster, MA, USA. Electronic address: rgogal@uga.edu. |
| المصدر: | Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2024 Feb; Vol. 268, pp. 110700. Date of Electronic Publication: 2024 Jan 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Country of Publication: Netherlands NLM ID: 8002006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2534 (Electronic) Linking ISSN: 01652427 NLM ISO Abbreviation: Vet Immunol Immunopathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] Elsevier Scientific. |
| مواضيع طبية MeSH: | Propolis*/pharmacology , Bee Venoms*/pharmacology, Animals ; Dogs ; Humans ; Horses ; Bees ; Apitherapy/veterinary ; Chickens ; Lymphocytes |
| مستخلص: | Apitherapy is a form of alternative medicine that utilizes products from the western honeybee (Apis mellifera), including honey, propolis, and honeybee venom, to improve the health status of human patients by altering host immunity. An added benefit of these products is that they are nutraceuticals and relatively inexpensive to aquire. Currently, little is known about the use of honeybee products in veterinary species, as well as their impact on host immunity. In the present in vitro study, honey, propolis, and honeybee venom were co-cultured with enriched canine, equine, and chicken peripheral blood lymphocytes (PBLs) with cell proliferation, cell viability/apoptosis, and cellular morphology evaluated. Concanavalin A (Con A) and dexamethasone were used as stimulatory and suppressive controls, respectively. Honeybee products' effects on the three veterinary species varied by product and the species. Honey stimulated the PBLs proliferation in all three species but also displayed some increased cytotoxicity. Propolis stimulated proliferation in canine and equine PBLs, however, it suppressed proliferation in the chicken PBLs. Honeybee venom was the strongest PBL stimulant for all three species and in the equine, surpassed the stimulant response of Con A and yet, enhanced PBL cell viability post culture. In summary, the results of this preliminary in vitro study show that these three honeybee products do impact lymphocyte proliferation and viability in dogs, horses, and chickens, and that more research both in vitro and in vivo will be necessary to draw conclusions regarding their future use as immune stimulants or inhibitors. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: We have nothing to declare with regards to this study. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apitherapy; Honey; Lymphocytes; Propolis; Venom; Veterinary |
| المشرفين على المادة: | 9009-62-5 (Propolis) 0 (Bee Venoms) |
| تواريخ الأحداث: | Date Created: 20240113 Date Completed: 20240129 Latest Revision: 20240129 |
| رمز التحديث: | 20240129 |
| DOI: | 10.1016/j.vetimm.2023.110700 |
| PMID: | 38217942 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-2534 |
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| DOI: | 10.1016/j.vetimm.2023.110700 |