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Accelerometer-based sleep metrics and gut microbiota during adolescence: Association findings from a Brazilian population-based birth cohort.

التفاصيل البيبلوغرافية
العنوان: Accelerometer-based sleep metrics and gut microbiota during adolescence: Association findings from a Brazilian population-based birth cohort.
المؤلفون: Carpena MX; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil. Electronic address: marinacarpena_@hotmail.com., Barros AJ; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil. Electronic address: abarros.epi@gmail.com., Comelli EM; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada; Joannah and Brian Lawson Centre for Child Nutrition, Faculty of Medicine, University of Toronto, ON, Canada. Electronic address: elena.comelli@utoronto.ca., López-Domínguez L; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada; Translational Medicine Program, Hospital for Sick Children, Toronto, ON, Canada., Alves ED; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil. Electronic address: etienediasnutri@gmail.com., Wendt A; Programa de Pós-Graduação Em Tecnologia Em Saúde, Pontifícia Universidade Católica Do Paraná, Curitiba, Brazil. Electronic address: andreatwendt@gmail.com., Crochemore-Silva I; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil; Postgraduate Program in Physical Education, Federal University of Pelotas, RS, Brazil. Electronic address: inacio_cms@yahoo.com.br., Bandsma RH; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada; Translational Medicine Program, Hospital for Sick Children, Toronto, ON, Canada. Electronic address: robert.bandsma@sickkids.ca., Santos IS; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil. Electronic address: inasantos.epi@gmail.com., Matijasevich A; Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil. Electronic address: amatija@yahoo.com., Borges MC; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: m.c.borges@bristol.ac.uk., Tovo-Rodrigues L; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil. Electronic address: luciana.tovo@gmail.com.
المصدر: Sleep medicine [Sleep Med] 2024 Feb; Vol. 114, pp. 203-209. Date of Electronic Publication: 2024 Jan 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2000-
مواضيع طبية MeSH: Gastrointestinal Microbiome*, Child ; Humans ; Accelerometry ; Birth Cohort ; Brazil ; Cohort Studies ; RNA, Ribosomal, 16S/genetics ; Sleep ; Adolescent
مستخلص: Background: Sleep and gut microbiota are emerging putative risk factors for several physical, mental, and cognitive conditions. Sleep deprivation has been shown to be linked with unhealthy microbiome environments in animal studies. However, in humans, the results are mixed. Epidemiological studies evaluating the effect of accelerometer-based sleep measures on gut microbiome are scarce. This study aims to explore the relationship between sleep duration and efficiency with the gut microbiota in adolescence.
Methods: A subsample of 352 participants from the 2004 Pelotas (Brazil) Birth Cohort Study with sleep and fecal microbiota data available were included in the study. Sleep duration and sleep efficiency were obtained from actigraphy information at 11 years old whereas microbiota information from fecal samples was collected at 12 years. The fecal microbiota was analyzed via Illumina MiSeq (16S rRNA V3-V4 region) and the UNOISE pipeline. Alpha was assessed in QIIME2. Association measures for sleep variables and microbial α-diversity, and bacterial relative abundance were assessed through generalized models (linear and logistic regression), adjusting for maternal and child variables confounders.
Results: Adjusted models showed that sleep duration was positively associated with Simpson index of α-diversity (β = 0.003; CI95 %: 0.00004; 0.01). Both sleep duration (OR = 0.43; CI95 % 0.25; 0.74) and efficiency (OR = 0.55; CI95 % 0.38; 0.78) were associated with lower Bacteroidetes abundance.
Conclusion: Our results suggest that sleep duration and efficiency are linked to gut microbiota diversity and composition even with 1-2 years gap from exposure to outcome. The findings support the role of sleep in the gut-brain axis as well as provide insights on how to improve microbiota health.
Competing Interests: Declaration of competing interest EMC reports grants from the Natural Sciences and Engineering Research Council of Canada and from the Canadian Institutes of Health Research while this study was being conducted, has received research support from Lallemand Health Solutions and Ocean Spray, and consultant fees or speaker and travel support from Danone and Lallemand Health Solutions (All are outside of this study).
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Actigraphy; Adolescence; Firmicutes/bacteroidetes ratio; Gut microbiota; Sleep; α-diversity
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20240114 Date Completed: 20240215 Latest Revision: 20240215
رمز التحديث: 20240215
DOI: 10.1016/j.sleep.2023.12.028
PMID: 38219656
قاعدة البيانات: MEDLINE
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