دورية أكاديمية
Enhancing diagnostic precision for acute chest syndrome in sickle cell disease: insights from dual-energy CT lung perfusion mapping.
| العنوان: | Enhancing diagnostic precision for acute chest syndrome in sickle cell disease: insights from dual-energy CT lung perfusion mapping. |
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| المؤلفون: | Chamberlin JH; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Ogbonna A; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Abrol S; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Maisuria D; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Miller E; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., McGuire A; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Knight H; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., O'Doherty J; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA.; Siemens Medical Solutions, Malvern, PA, USA., Baruah D; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Schoepf UJ; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Munden RF; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA., Kabakus IM; Department of Radiology and Radiologic Science, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC, USA. kabakus@musc.edu. |
| المصدر: | Emergency radiology [Emerg Radiol] 2024 Feb; Vol. 31 (1), pp. 73-82. Date of Electronic Publication: 2024 Jan 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag New York Inc Country of Publication: United States NLM ID: 9431227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-1435 (Electronic) Linking ISSN: 10703004 NLM ISO Abbreviation: Emerg Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Springer-Verlag New York Inc Original Publication: Baltimore, MD. : Williams & Wilkins, c1994- |
| مواضيع طبية MeSH: | Acute Chest Syndrome*/diagnostic imaging , Pulmonary Embolism*/diagnostic imaging , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/diagnostic imaging , Iodine*, Humans ; Retrospective Studies ; Angiography/methods ; Reproducibility of Results ; Tomography, X-Ray Computed/methods ; Lung ; Perfusion |
| مستخلص: | Purpose: Acute chest syndrome (ACS) is secondary to occlusion of the pulmonary vasculature and a potentially life-threatening complication of sickle cell disease (SCD). Dual-energy CT (DECT) iodine perfusion map reconstructions can provide a method to visualize and quantify the extent of pulmonary microthrombi. Methods: A total of 102 patients with sickle cell disease who underwent DECT CTPA with perfusion were retrospectively identified. The presence or absence of airspace opacities, segmental perfusion defects, and acute or chronic pulmonary emboli was noted. The number of segmental perfusion defects between patients with and without acute chest syndrome was compared. Sub-analyses were performed to investigate robustness. Results: Of the 102 patients, 68 were clinically determined to not have ACS and 34 were determined to have ACS by clinical criteria. Of the patients with ACS, 82.4% were found to have perfusion defects with a median of 2 perfusion defects per patient. The presence of any or new perfusion defects was significantly associated with the diagnosis of ACS (P = 0.005 and < 0.001, respectively). Excluding patients with pulmonary embolism, 79% of patients with ACS had old or new perfusion defects, and the specificity for new perfusion defects was 87%, higher than consolidation/ground glass opacities (80%). Conclusion: DECT iodine map has the capability to depict microthrombi as perfusion defects. The presence of segmental perfusion defects on dual-energy CT maps was found to be associated with ACS with potential for improved specificity and reclassification. (© 2024. The Author(s), under exclusive licence to American Society of Emergency Radiology (ASER).) |
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| فهرسة مساهمة: | Keywords: Acute chest syndrome; Dual-energy computed tomography; Perfusion mapping; Pulmonary embolism; Sickle cell disease |
| المشرفين على المادة: | 9679TC07X4 (Iodine) |
| تواريخ الأحداث: | Date Created: 20240115 Date Completed: 20240202 Latest Revision: 20240703 |
| رمز التحديث: | 20240704 |
| DOI: | 10.1007/s10140-024-02200-w |
| PMID: | 38224366 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1438-1435 |
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| DOI: | 10.1007/s10140-024-02200-w |