دورية أكاديمية
Causal effect of age first had sexual intercourse and lifetime number of sexual partners on cervical cancer.
| العنوان: | Causal effect of age first had sexual intercourse and lifetime number of sexual partners on cervical cancer. |
|---|---|
| المؤلفون: | Zhou YY; Department of Obstetrics and Gynecology, Anhui Provincial Children's Hospital, Children's Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China., Chang M; Anhui Province Maternity and Child Healthcare Hospital, Hefei, Anhui, 230051, China., Li CP; Department of Obstetrics and Gynecology, Hefei University of Technology Hospital, Hefei, Anhui, 230051, China., Han XL; Department of Obstetrics and Gynecology, Anhui Provincial Children's Hospital, Children's Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China., Fang P; Department of Oncology, The 902nd Hospital of the PlA Joint Logistics Support Force, Bengbu, Anhui, 233000, China., Xia XP; Department of Obstetrics and Gynecology, Anhui Provincial Children's Hospital, Children's Hospital of Fudan University Anhui Hospital, Children's Hospital of Anhui Medical University, Hefei, Anhui, 230051, China. |
| المصدر: | Heliyon [Heliyon] 2023 Dec 22; Vol. 10 (1), pp. e23758. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Elsevier Ltd, [2015]- |
| مستخلص: | Objective: In this study, we aimed to investigate whether age first had sexual intercourse (AFSI) and lifetime number of sexual partners (LNSP) have a direct causal effect on cervical cancer by Mendelian randomization (MR) analysis. Methods: Four approaches were used for MR Analysis, including MR-Egger, weighted method, weighted median, and inverse variance weighted (IVW). MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) as well as MR-Egger regression analysis were conducted to detect whether there was pleiotropy between IVs and outcome, and the outlier SNPs can be detected by MR-PRESSO. The presence or absence of heterogeneity among IVs was suggested according to Cochran's Q statistic. Leave-one-out sensitivity analysis was performed to identify and remove SNPs which could independently change the results. We corrected the results using Bonferroni correction. Results: From the results of IVW, AFSI had a negative effect on cervical cancer (OR = 0.996, 95 % CI: 0.995, 0.998 P = 1.70E-07), which still persisted after Bonferroni correction. However, no causal effect of LNSP on cervical cancer was found according to the IVW results (OR = 1.003, 95 % CI: 1.000, 1.007, P = 0.071). From the results of MR-PRESSO and MR-Egger, no SNP with horizontal pleiotropy between cervical cancer was detected and no SNP was identified as an outlier SNP. Cochran's Q statistic suggested that no heterogeneity existed among IVs of AFSI and LNSP. According to Leave-one-out analysis, the results of MR did not change after excluding any single IV. Conclusion: This MR study reveals that early AFSI has a causal effect on cervical cancer. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors. Published by Elsevier Ltd.) |
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| فهرسة مساهمة: | Keywords: Age first had sexual intercourse; Cervical cancer; Genetics; Lifetime number of sexual partners; Mendelian randomization |
| تواريخ الأحداث: | Date Created: 20240116 Latest Revision: 20240117 |
| رمز التحديث: | 20240117 |
| مُعرف محوري في PubMed: | PMC10788439 |
| DOI: | 10.1016/j.heliyon.2023.e23758 |
| PMID: | 38226234 |
| قاعدة البيانات: | MEDLINE |
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